采用抗压强度参数对苯巴比妥-微晶纤维素片进行质量控制。
Use of the crushing strength parameter for quality control of phenobarbital-microcrystalline cellulose tablets.
作者信息
Souto C, Gómez-Amoza J L, Landín M, Vila-Jato J L, Concheiro A, Martínez-Pacheco R
机构信息
Departamento De Farmacología, Farmacia Y Technología Farmacéutica Facultad De Farmacia, Santiago De Compostela, Spain.
出版信息
Farmaco. 1989 Jul-Aug;44(7-8):731-7.
Three variables of the tablet manufacturing process (duration of mixing with lubricant, maximum compression force and compression rate) were studied for their effects on various properties of direct compression phenobarbital-microcrystalline cellulose tablets. Mixing time and maximum compression force were found to have a marked influence on friability and dissolution rate; crushing strength was found to be a useful parameter for quality control.
研究了片剂生产过程中的三个变量（与润滑剂混合的持续时间、最大压缩力和压缩速率）对直接压片苯巴比妥-微晶纤维素片各种性质的影响。发现混合时间和最大压缩力对脆碎度和溶出速率有显著影响；抗压强度被发现是质量控制的一个有用参数。
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