新诊断多发性硬化症患者中copeptin与皮质醇的关联

Association of copeptin and cortisol in newly diagnosed multiple sclerosis patients.

作者信息

Baranowska-Bik Agnieszka, Kochanowski Jan, Uchman Dorota, Litwiniuk Anna, Kalisz Malgorzata, Martynska Lidia, Wolinska-Witort Ewa, Baranowska Boguslawa, Bik Wojciech

机构信息

Department of Endocrinology, Centre of Postgraduate Medical Education, Bielanski Hospital, Ceglowska 80, 01-809 Warsaw, Poland.

Department of Neurology, Medical University of Warsaw, Bielanski Hospital, Ceglowska 80, 01-809 Warsaw, Poland.

出版信息

J Neuroimmunol. 2015 May 15;282:21-4. doi: 10.1016/j.jneuroim.2015.03.011. Epub 2015 Mar 11.

DOI:10.1016/j.jneuroim.2015.03.011

PMID:25903724

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Obesity may increase the risk of developing MS. The aim of this study was to evaluate copeptin and cortisol plasma levels in newly diagnosed untreated MS patients and to determine whether copeptin and cortisol are related to the patients' clinical statuses. We report that copeptin and cortisol were higher in overweight/obese MS patients. Positive correlations were observed between the two parameters. We conclude that alterations of copeptin and cortisol levels in multiple sclerosis patients may be related to adiposity. An increase in cortisol may also be associated with copeptin secretion.

摘要

多发性硬化症（MS）是一种中枢神经系统的慢性自身免疫性疾病。肥胖可能会增加患MS的风险。本研究的目的是评估新诊断的未经治疗的MS患者体内的copeptin和皮质醇血浆水平，并确定copeptin和皮质醇是否与患者的临床状态相关。我们报告称，超重/肥胖的MS患者体内的copeptin和皮质醇水平较高。观察到这两个参数之间存在正相关。我们得出结论，多发性硬化症患者体内copeptin和皮质醇水平的改变可能与肥胖有关。皮质醇的增加也可能与copeptin的分泌有关。