Blom Jan Dirk, Coebergh Jan Adriaan F, Lauw René, Sommer Iris E C
Parnassia Psychiatric Institute , The Hague , Netherlands ; Department of Psychiatry, University of Groningen , Groningen , Netherlands.
Department of Neurology, Ashford and St. Peter's Hospitals , Chertsey , UK ; Department of Neurology, St. George's Hospital , London , UK.
Front Psychiatry. 2015 Apr 7;6:46. doi: 10.3389/fpsyt.2015.00046. eCollection 2015.
Musical hallucinations are relatively rare auditory percepts which, due to their intrusive nature and the accompanying fear of impending mental decline, tend to cause significant distress and impairment. Although their etiology and pathophysiology appear to be heterogeneous and no evidence-based treatment methods are available, case reports indicate that acetylcholinesterase inhibitors may yield positive results in patients with comorbid hearing loss. We present two female patients (aged 76 and 78 years) both of whom suffered from hearing impairment and practically incessant musical hallucinations. Both patients were successfully treated with the acetylcholinesterase inhibitor rivastigmine. Based on these two case descriptions and an overview of studies describing the use of acetylcholinesterase inhibitors in similar patients, we discuss possible mechanisms and propose further research on the use of acetylcholinesterase inhibitors for musical hallucinations experienced in concordance with hearing loss.
音乐幻觉是相对罕见的听觉感知，由于其侵扰性以及随之而来的对即将出现的智力衰退的恐惧，往往会导致严重的痛苦和功能损害。尽管其病因和病理生理学似乎具有异质性，且尚无循证治疗方法，但病例报告表明，乙酰胆碱酯酶抑制剂可能对合并听力损失的患者产生积极效果。我们报告了两名女性患者（分别为76岁和78岁），她们均患有听力障碍且几乎持续出现音乐幻觉。两名患者均使用乙酰胆碱酯酶抑制剂卡巴拉汀成功治疗。基于这两个病例描述以及对描述在类似患者中使用乙酰胆碱酯酶抑制剂的研究的综述，我们讨论了可能的机制，并提议进一步研究乙酰胆碱酯酶抑制剂用于与听力损失相关的音乐幻觉的情况。
