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具有广义成功/失败感染遗传学的宿主-寄生虫协同进化动力学

Host-parasite coevolutionary dynamics with generalized success/failure infection genetics.

作者信息

Engelstädter Jan

机构信息

School of Biological Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.

出版信息

Am Nat. 2015 May;185(5):E117-29. doi: 10.1086/680476. Epub 2015 Feb 25.

Abstract

Host-parasite infection genetics can be more complex than envisioned by classic models such as the gene-for-gene or matching-allele models. By means of a mathematical model, I investigate the coevolutionary dynamics arising from a large set of generalized models of infection genetics in which hosts are either fully resistant or fully susceptible to a parasite, depending on the genotype of both individuals. With a single diploid interaction locus in the hosts, many of the infection genetic models produce stable or neutrally stable genotype polymorphisms. However, only a few models, which are all different versions of the matching-allele model, lead to sustained cycles of genotype frequency fluctuations in both interacting species ("Red Queen" dynamics). By contrast, with two diploid interaction loci in the hosts, many infection genetics models that cannot be classified as one of the standard infection genetics models produce Red Queen dynamics. Sexual versus asexual reproduction and, in the former case, the rate of recombination between the interaction loci have a large impact on whether Red Queen dynamics arise from a given infection genetics model. This may have interesting but as yet unexplored implications with respect to the Red Queen hypothesis for the evolution of sex.

摘要

宿主-寄生虫感染遗传学可能比基因对基因或匹配等位基因模型等经典模型所设想的更为复杂。通过一个数学模型,我研究了一大类感染遗传学广义模型所产生的协同进化动态,在这些模型中,宿主对寄生虫要么完全抗性,要么完全易感,这取决于两者的基因型。在宿主中有一个单倍体相互作用位点时,许多感染遗传模型会产生稳定或中性稳定的基因型多态性。然而,只有少数模型,即匹配等位基因模型的所有不同版本,会导致两个相互作用物种的基因型频率波动持续循环(“红皇后”动态)。相比之下,在宿主中有两个二倍体相互作用位点时,许多无法归类为标准感染遗传学模型之一的感染遗传模型会产生红皇后动态。有性生殖与无性生殖,以及在前一种情况下,相互作用位点之间的重组率,对给定的感染遗传模型是否产生红皇后动态有很大影响。这可能对性进化的红皇后假设有有趣但尚未探索的影响。

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