Ren Jingyun, Yuan Leilei, Wen Guanghua, Yang Jigang
Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, PR China.
Department of Nuclear Medcine, Jin Hua Municipal Central Hospital, Zhe Jiang, PR China
Acta Radiol. 2016 Apr;57(4):487-93. doi: 10.1177/0284185115581541. Epub 2015 Apr 22.
Anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid (anti-3-18F-FACBC) positron emission tomography/computed tomography (PET/CT), 11 C-choline PET/CT, 111In-capromab pendetide, and T2-weighted magnetic resonance imaging (MRI) have been used for detecting prostate carcinoma relapse.
To systematically review and perform a meta-analysis of published data regarding the performance of 18F-FACBC PET/CT in the diagnosis of recurrent prostate carcinoma.
A comprehensive review of the literature regarding the role of 18F-FACBC PET/CT in the diagnosis of recurrent prostate carcinoma was performed. Pooled sensitivity, specificity, and the area under the receiver-operating characteristic of 18F-FACBC PET/CT in the diagnosis of recurrent prostate carcinoma were calculated based on the included studies.
Six studies comprising 251 patients, suspicious of prostate carcinoma recurrence, were included in this meta-analysis. 18F-FACBC PET/CT had an 87% pooled sensitivity, 66% pooled specificity, 0.93 the area under the receiver-operating characteristic curve on a per patient-based analysis in detecting prostate carcinoma recurrence.
18F-FACBC PET/CT was a non-invasive, metabolic imaging technique in the diagnosis of prostate carcinoma relapse.
1-氨基-3-[18F]氟环丁烷-1-羧酸（anti-3-18F-FACBC）正电子发射断层扫描/计算机断层扫描（PET/CT）、11C-胆碱PET/CT、111In-卡泊单抗和T2加权磁共振成像（MRI）已用于检测前列腺癌复发。
系统评价并对已发表的关于18F-FACBC PET/CT在复发性前列腺癌诊断中性能的数据进行荟萃分析。
对有关18F-FACBC PET/CT在复发性前列腺癌诊断中作用的文献进行全面综述。根据纳入的研究计算18F-FACBC PET/CT在复发性前列腺癌诊断中的合并敏感性、特异性和受试者操作特征曲线下面积。
本荟萃分析纳入了6项研究，共251例怀疑前列腺癌复发的患者。在基于每位患者的分析中，18F-FACBC PET/CT检测前列腺癌复发的合并敏感性为87%，合并特异性为66%，受试者操作特征曲线下面积为0.93。
18F-FACBC PET/CT是诊断前列腺癌复发的一种非侵入性代谢成像技术。
