Yang Ji-Chun, Dong Xiao-Xi, Mu Zhi-Ming, Jin Wen-Dong, Huang He, Lu Yu, Chen Zhu-Ying, Li Ying-Xin
Chinese Academy of Medical Science &Peking Union Medical College, Institute of Biomedical Engineering, Laboratory of Laser Medicine, No.236, Baidi Road, Tianjin, 300192, China.
Chinese Academy of Medical Science &Peking Union Medical College, Institute of Biomedical Engineering, Laboratory of Laser Medicine, No.236, Baidi Road, Tianjin, 300192, China ; Xiao-xi Dong and Ji-chun Yang contributed equally to this work.
Biomed Opt Express. 2015 Mar 24;6(4):1451-63. doi: 10.1364/BOE.6.001451. eCollection 2015 Apr 1.
For predicting pain stimulation effects and avoiding damage in 1940nm laser evoked potentials (LEPs) experiments, a 2-layer finite element model (FEM-2) was constructed. A series of experiments were conducted on ex-vivo pig skin pieces to verify temperature distribution predicted by this model. Various laser powers and beam radii were employed. Experimental data of time-dependent temperature responses in different sub-skin depths and space-dependent surface temperature was recorded by thermocouple instrument. By comparing with the experimental data and model results, FEM-2 model was proved to predict temperature distributions accurately. A logarithmic relationship between laser power density and temperature increment was revealed by the results. It is concluded that power density is an effective parameter to estimate pain and damage effect. The obtained results also indicated that the proposed FEM-2 model can be extended to predict pain and damage thresholds of human skin samples and thus contribute to LEPs study.
为了在1940纳米激光诱发电位（LEPs）实验中预测疼痛刺激效果并避免损伤，构建了一个两层有限元模型（FEM - 2）。对离体猪皮块进行了一系列实验，以验证该模型预测的温度分布。采用了各种激光功率和光束半径。通过热电偶仪器记录了不同皮肤深度随时间变化的温度响应以及随空间变化的表面温度的实验数据。通过将实验数据与模型结果进行比较，证明FEM - 2模型能够准确预测温度分布。结果揭示了激光功率密度与温度增量之间的对数关系。得出结论，功率密度是估计疼痛和损伤效果的有效参数。所得结果还表明，所提出的FEM - 2模型可以扩展到预测人体皮肤样本的疼痛和损伤阈值，从而有助于LEPs研究。
