Khouly Ismael, Veitz-Keenan Analia
NYU College of Dentistry, New York, USA.
Evid Based Dent. 2015 Mar;16(1):21-2. doi: 10.1038/sj.ebd.6401081.
The Cochrane Oral Health Group's Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), Medline and Embase databases were searched with no language or date restrictions.
Two reviewers independently selected studies. Randomised controlled trials (RCTs) of different techniques and materials for augmenting the maxillary sinus for rehabilitation with dental implants that reported the outcome of implant success or failure at least four months after initial loading were considered.
Data were extracted independently by two reviewers and study risk of bias assessed. Results were expressed using fixed-effect models as there were either fewer than four studies or we used Peto odds ratios (ORs) for dichotomous data when there were zero cells in either the treatment or control or both arms and the number of trials was small.
Eighteen trials involving 650 patients were included. Five studies were considered to be at low risk of bias, 11 at high risk and two of unclear risk. Four trials (102 patients) evaluated short implants (5 to 8.5 mm long) as an alternative to sinus lift in bone with residual height between 4 and 9 mm. One year after loading there was insufficient evidence to claim differences between the two procedures for prosthesis failure (OR (Peto) 0.37, 95% confidence interval (CI) 0.05 to 2.68; three trials) or implant failure (OR (Peto) 0.44, 95% CI 0.10 to 1.99; four trials). There was however an increase in complications at treated sites when undertaking the sinus lift (OR (Peto) 4.77, 95% CI 1.79 to 12.71, P value = 0.002; four trials).Fourteen trials (548 patients) compared different sinus lift techniques. Only three comparisons included more than one trial. These were bone graft versus no bone graft, autogenous bone versus bone substitute, bone graft with or without platelet-rich plasma (PRP). There was insufficient evidence to claim a benefit for any of these techniques for the primary outcomes of prosthesis and implant failure.The other comparisons with single studies were rotary versus piezosurgery to open a lateral sinus window, two different bone substitutes, use or not of a membrane to seal the lateral window, one- versus two-stage lateral sinus lift, two-stage granular bone versus one-stage autogenous bone blocks and crestal versus lateral sinus lift; two trials compared three different crestal sinus lifting techniques: rotatory versus hand malleting (patients preferred rotatory instruments over hand malleting) and hand versus electric malleting. There was no evidence of a benefit for any sinus lift procedure compared to any other for the primary outcomes prosthesis or implant failure.
There is moderate quality evidence which is insufficient to determine whether sinus lift procedures in bone with residual height between 4 and 9 mm are more or less successful than placing short implants (5 to 8.5 mm) in reducing prosthesis or implant failure up to one year after loading. However, there are more complications at sites treated with sinus lift procedures. Many trials compared different sinus lift procedures and none of these indicated that one procedure reduced prosthetic or implant failures when compared to the other. Based on low quality evidence, patients may prefer rotary instruments over hand malleting for crestal sinus lift.
检索了Cochrane口腔健康小组试验注册库、Cochrane对照试验中央注册库(CENTRAL)、Medline和Embase数据库,无语言或日期限制。
两名 reviewers 独立选择研究。纳入了关于使用不同技术和材料进行上颌窦提升以配合牙种植体修复的随机对照试验(RCT),这些研究报告了初次加载后至少四个月的种植体成功或失败结果。
由两名 reviewers 独立提取数据并评估研究的偏倚风险。由于研究少于四项,或者当治疗组或对照组或两组中出现零单元格且试验数量较少时,对于二分数据我们使用Peto比值比(OR),因此结果采用固定效应模型表示。
纳入了18项试验,涉及650例患者。5项研究被认为偏倚风险低,11项偏倚风险高,2项风险不明确。4项试验(102例患者)评估了短种植体(长度为5至8.5毫米)作为剩余高度在4至9毫米的骨中进行上颌窦提升替代方法的效果。加载一年后,没有足够证据表明两种方法在假体失败方面存在差异(OR(Peto)0.37,95%置信区间(CI)0.(此处原文有误,应为0.05)至2.68;三项试验)或种植体失败方面存在差异(OR(Peto)0.44,95%CI 0.10至1.99;四项试验)。然而,进行上颌窦提升时治疗部位的并发症有所增加(OR(Peto)4.77,95%CI 1.79至12.71,P值 = 0.002;四项试验)。14项试验(548例患者)比较了不同上颌窦提升技术。只有三项比较纳入了不止一项试验。这些比较是骨移植与非骨移植、自体骨与骨替代物、有或无富血小板血浆(PRP)的骨移植。没有足够证据表明这些技术中的任何一种在假体和种植体失败的主要结局方面有优势。其他单项研究的比较包括旋转式与压电式手术打开外侧上颌窦窗口、两种不同的骨替代物、是否使用膜封闭外侧窗口、一期与二期外侧上颌窦提升、二期颗粒骨与一期自体骨块以及嵴顶与外侧上颌窦提升;两项试验比较了三种不同的嵴顶上颌窦提升技术:旋转式与手动锤击(患者更喜欢旋转器械而非手动锤击)以及手动与电动锤击。没有证据表明任何上颌窦提升手术在假体或种植体失败的主要结局方面比其他手术更有优势。
有中等质量的证据,但不足以确定在剩余高度为4至9毫米的骨中进行上颌窦提升手术在减少加载后一年内的假体或种植体失败方面是否比植入短种植体(5至8.5毫米)更成功或更不成功。然而,上颌窦提升手术治疗部位的并发症更多。许多试验比较了不同的上颌窦提升手术,与其他手术相比,没有一项表明一种手术能减少假体或种植体失败。基于低质量证据,在嵴顶上颌窦提升时患者可能更喜欢旋转器械而非手动锤击。