Mukiibi J M, Paul B
East Afr Med J. 1989 Mar;66(3):155-61.
Twenty three Zimbabwean African patients who satisfied the French-American-British(FAB) diagnostic criteria for the myelodysplastic syndromes(MDS) at Godfrey Huggins School of Medicine, University of Zimbabwe, between July 1985 and June 1987 are presented. The disorders appear not to behave differently from those reported in Caucasian populations with regard to clinical and haematological features. Refractory anaemia (RA) occurred in 12 (52.2%) patients; refractory anaemia with ringed sideroblasts (RARS) in 4 (17.4%) patients; refractory anaemia with excess blasts (RAEB) in 2 (8.7%) patients; refractory anaemia with excess blasts in transformation (RAEB-T) in 3 (13.0%) patients; while chronic myelomonocytic leukaemia (CMML) was observed in 2 (8.7%) patients. In 19 cases, the disease was primary and in 4 prior exposure to myelotoxic agents resulted in secondary MDS. The clinical significance of recognising the disorders is briefly high-lighted together with our current treatment protocol.
本文介绍了1985年7月至1987年6月间，在津巴布韦大学戈弗雷·哈金斯医学院符合法美英（FAB）骨髓增生异常综合征（MDS）诊断标准的23例津巴布韦非洲患者。就临床和血液学特征而言，这些疾病的表现似乎与白种人群中报道的并无不同。12例（52.2%）患者为难治性贫血（RA）；4例（17.4%）患者为难治性贫血伴环形铁粒幼细胞（RARS）；2例（8.7%）患者为难治性贫血伴原始细胞增多（RAEB）；3例（13.0%）患者为难治性贫血伴原始细胞增多转变型（RAEB-T）；2例（8.7%）患者为慢性粒单核细胞白血病（CMML）。19例患者疾病为原发性，4例既往接触骨髓毒性药物导致继发性MDS。文中简要强调了认识这些疾病的临床意义以及我们目前的治疗方案。
