接受大截肢手术的糖尿病患者的生存率与恶性疾病患者相当。
Survival of diabetes patients with major amputation is comparable to malignant disease.
作者信息
Hoffmann Martin, Kujath Peter, Flemming Annette, Proß Moritz, Begum Nehara, Zimmermann Markus, Keck Tobias, Kleemann Markus, Schloericke Erik
机构信息
University Clinic of Schleswig-Holstein, Luebeck, Germany
University Clinic of Schleswig-Holstein, Luebeck, Germany.
出版信息
Diab Vasc Dis Res. 2015 Jul;12(4):265-71. doi: 10.1177/1479164115579005. Epub 2015 Apr 28.
INTRODUCTION
Almost all studies on diabetic foot syndrome focused on prevention of amputation and did not investigate long-term prognosis and survival of patients as a primary outcome parameter.
METHODS
We did a retrospective cohort study including 314 patients who had diabetic foot syndrome and underwent amputation between December 1995 and January 2001.
RESULTS
A total of 48% of patients received minor amputation (group I), 15% only major amputation (group II) and 36% initially underwent a minor amputation that was followed by a major amputation (group III). Statistically significant differences were observed in comparison of the median survival of group I to group II (51 vs. 40 months; p = 0.016) and of group II to group III (40 vs. 55 months; p = 0.003).
DISCUSSION
The prognosis of patients with major amputation due to diabetic foot syndrome is comparable to patients with malignant diseases. Vascular interventions did not improve the individual prognosis of patients.
引言
几乎所有关于糖尿病足综合征的研究都集中在预防截肢方面，并未将患者的长期预后和生存率作为主要结局参数进行调查。
方法
我们进行了一项回顾性队列研究，纳入了1995年12月至2001年1月期间患有糖尿病足综合征并接受截肢手术的314例患者。
结果
共有48%的患者接受了小截肢（第一组），15%仅接受了大截肢（第二组），36%最初接受了小截肢，随后又接受了大截肢（第三组）。第一组与第二组的中位生存期比较（51对40个月；p = 0.016）以及第二组与第三组的中位生存期比较（40对55个月；p = 0.003），均观察到统计学上的显著差异。
讨论
因糖尿病足综合征接受大截肢的患者的预后与患有恶性疾病的患者相当。血管干预并未改善患者的个体预后。
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