利用延长的阳离子两亲性聚脯氨酸螺旋靶向细胞内细菌。
Targeting intracellular bacteria with an extended cationic amphiphilic polyproline helix.
作者信息
Nepal Manish, Thangamani Shankar, Seleem Mohamed N, Chmielewski Jean
机构信息
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907-2027, USA.
出版信息
Org Biomol Chem. 2015 Jun 7;13(21):5930-6. doi: 10.1039/c5ob00227c.
An extended cationic and amphiphilic polyproline helix (CAPH) is described with a dual mode of action: effective cell penetration of human macrophages, and potent antimicrobial activity in vitro against both Gram-positive and negative pathogens, including Acinetobacter baumannii, Escherichia coli O157 and Bacillus anthracis. This dual action was successfully combined to clear pathogenic bacteria (Brucella and Salmonella) residing within macrophages.
本文描述了一种具有双重作用模式的延伸阳离子两亲性聚脯氨酸螺旋（CAPH）：它能有效穿透人类巨噬细胞，并且在体外对革兰氏阳性和阴性病原体（包括鲍曼不动杆菌、大肠杆菌O157和炭疽芽孢杆菌）具有强大的抗菌活性。这种双重作用成功地结合起来清除了巨噬细胞内寄生的病原菌（布鲁氏菌和沙门氏菌）。
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