晚期胰腺癌且血清白细胞介素-6水平高的患者特征
Characterization of patients with advanced pancreatic cancer and high serum interleukin-6 levels.
作者信息
Miura Tomofumi, Mitsunaga Shuichi, Ikeda Masafumi, Shimizu Satoshi, Ohno Izumi, Takahashi Hideaki, Furuse Junji, Inagaki Masatoshi, Higashi Sayumi, Kato Hiroyuki, Terao Kimio, Ochiai Atsushi
机构信息
From the *Department of Hepatobiliary and Pancreatic Oncology, †Department of Palliative Medicine, and ‡Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa; §Department of Medical Oncology, Kyorin University School of Medicine, Mitaka; ∥Center for Suicide Prevention, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira; and ¶Chugai Pharmaceutical Co, Ltd, Tokyo, Japan.
出版信息
Pancreas. 2015 Jul;44(5):756-63. doi: 10.1097/MPA.0000000000000335.
OBJECTIVES
High serum level of interleukin 6 (IL-6) is associated with high degree of tumor progression and systemic weakness. Anti-IL-6 therapy possibly improves the deterioration of clinical characteristics in patients with high IL-6 level. However, IL-6-related factors in patients with treatment-naive advanced pancreatic cancer (PC) have not been established. The goal of this study was to identify IL-6-related factors in patients with advanced PC who were scheduled to undergo first-line chemotherapy.
METHODS
Patients with treatment-naive advanced PC were eligible for inclusion in this study. Patients who did not receive first-line chemotherapy were excluded. Serum IL-6 levels and clinical parameters were prospectively recorded. Analyses were performed to identify risk factors for high IL-6 levels.
RESULTS
Eighty patients were analyzed. IL-6-related factors were advanced age (P < 0.01), the presence of liver metastasis (P < 0.01), the large volume of liver metastasis (P < 0.01), severe fatigue (P = 0.02), high carcinoembryonic antigen levels (P = 0.02), anemia (P < 0.01), and high C-reactive protein levels (P = 0.02) in multivariate analyses. Decreased skeletal muscle mass tended to be associated with high IL-6 levels.
CONCLUSIONS
High serum IL-6 was related to advanced age, the presence of hepatic metastasis, large tumor burden in liver, severe fatigue, high carcinoembryonic antigen, high C-reactive protein, and anemia in patients with treatment-naive advanced PC.
目的
血清白细胞介素6（IL-6）水平升高与肿瘤高度进展和全身虚弱相关。抗IL-6治疗可能改善IL-6水平高的患者临床特征的恶化。然而，未经治疗的晚期胰腺癌（PC）患者中与IL-6相关的因素尚未明确。本研究的目的是确定计划接受一线化疗的晚期PC患者中与IL-6相关的因素。
方法
未经治疗的晚期PC患者符合本研究纳入标准。未接受一线化疗的患者被排除。前瞻性记录血清IL-6水平和临床参数。进行分析以确定IL-6水平高的危险因素。
结果
对80例患者进行了分析。多因素分析中，与IL-6相关的因素有高龄（P<0.01）、存在肝转移（P<0.01）、肝转移灶体积大（P<0.01）、严重疲劳（P=0.02）、癌胚抗原水平高（P=0.02）、贫血（P<0.01）和C反应蛋白水平高（P=0.02）。骨骼肌质量降低往往与IL-6水平高相关。
结论
在未经治疗的晚期PC患者中，血清IL-6水平高与高龄、肝转移的存在、肝脏肿瘤负荷大、严重疲劳、癌胚抗原高、C反应蛋白高和贫血有关。
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