基因定义的恐惧诱发攻击行为中的脑源性神经营养因子（BDNF）及其前体（proBDNF）
Brain-derived neurotrophic factor (BDNF) and its precursor (proBDNF) in genetically defined fear-induced aggression.
作者信息
Ilchibaeva Tatiana V, Kondaurova Elena M, Tsybko Anton S, Kozhemyakina Rimma V, Popova Nina K, Naumenko Vladimir S
机构信息
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia.
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.
出版信息
Behav Brain Res. 2015 Sep 1;290:45-50. doi: 10.1016/j.bbr.2015.04.041. Epub 2015 Apr 28.
The brain-derived neurotrophic factor (BDNF), its precursor (proBDNF) and BDNF mRNA levels were studied in the brain of wild rats selectively bred for more than 70 generations for either high level or for the lack of affective aggressiveness towards man. Significant increase of BDNF mRNA level in the frontal cortex and increase of BDNF level in the hippocampus of aggressive rats was revealed. In the midbrain and hippocampus of aggressive rats proBDNF level was increased, whereas BDNF/proBDNF ratio was reduced suggesting the prevalence and increased influence of proBDNF in highly aggressive rats. In the frontal cortex, proBDNF level in aggressive rats was decreased. Thus, considerable structure-specific differences in BDNF and proBDNF levels as well as in BDNF gene expression between highly aggressive and nonaggressive rats were shown. The data suggested the implication of BDNF and its precursor proBDNF in the mechanism of aggressiveness and in the creation of either aggressive or nonaggressive phenotype.
对经过70多代选择性培育的野生大鼠大脑进行了研究，这些大鼠分为对人类具有高攻击性行为或缺乏情感攻击性两组。研究了脑源性神经营养因子（BDNF）及其前体（proBDNF）以及BDNF mRNA水平。结果显示，攻击性大鼠额叶皮质中BDNF mRNA水平显著升高，海马体中BDNF水平升高。在攻击性大鼠的中脑和海马体中，proBDNF水平升高，而BDNF/proBDNF比值降低，这表明proBDNF在高攻击性大鼠中占主导地位且影响增强。在额叶皮质中，攻击性大鼠的proBDNF水平降低。因此，高攻击性和非攻击性大鼠在BDNF和proBDNF水平以及BDNF基因表达方面存在明显的结构特异性差异。数据表明BDNF及其前体proBDNF参与了攻击性行为的机制以及攻击型或非攻击型表型的形成。
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