产OXA-23型鲍曼不动杆菌ST2和ST246在日本一家医院的传播。
Spread of OXA-23-producing Acinetobacter baumannii ST2 and ST246 in a hospital in Japan.
作者信息
Kubo Yumi, Komatsu Masaru, Tanimoto Emi, Sugimoto Keiichi, Tanaka Satoru, Migita Shiho, Kondo Yoko, Yano Sawa, Maehara Kuniho, Murata Ryoko, Nakamura Akihiro, Fujita Toshikazu, Kawata Yoichi
机构信息
FALCO Biosystems, Ltd, Okayama Laboratory Technical Section 2, Okayama, Japan.
Department of Clinical Laboratory Science, Faculty of Health Care, Tenri Health Care University, Nara, Japan.
出版信息
J Med Microbiol. 2015 Jul;64(7):739-744. doi: 10.1099/jmm.0.000077. Epub 2015 May 1.
A total of 1085 strains of Acinetobacter sp. obtained from 280 medical institutions in the Chugoku and Shikoku areas of Japan were investigated between 2011 and 2013. Among these strains, 20 (1.84 %) showing meropenem or imipenem resistance with a MIC of >4 μg ml- 1 were detected. Of these 20 strains, the bla(OXA-23) gene was detected in 17 strains isolated from the same institution. The PFGE patterns of the 17 strains were separated into two clusters, and multi-locus sequence typing showed the sequence types (STs) to be ST2 and ST246. This investigation demonstrated that A. baumannii ST2 of international clone II, which has rarely been isolated in Japan, has not yet spread nationwide.
2011年至2013年期间，对从日本中国和四国地区280家医疗机构获取的总共1085株不动杆菌属菌株进行了调查。在这些菌株中，检测到20株（1.84%）对美罗培南或亚胺培南耐药，其最低抑菌浓度（MIC）>4 μg/ml。在这20株菌株中，在从同一机构分离出的17株菌株中检测到bla(OXA-23)基因。17株菌株的脉冲场凝胶电泳（PFGE）图谱分为两个簇，多位点序列分型显示序列类型（STs）为ST2和ST246。这项调查表明，在日本很少分离到的国际克隆II的鲍曼不动杆菌ST2尚未在全国范围内传播。
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