Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
School of Pharmacy, Ardebil University of Medical Sciences, Ardebil, Iran.
Environ Toxicol Pharmacol. 2015 May;39(3):1161-9. doi: 10.1016/j.etap.2015.04.010. Epub 2015 Apr 20.
Benzene (C6H6) is an organic compound used in petrochemicals and numerous other industries. It is abundantly released to our environment as a chemical pollutant causing widespread human exposure. This study mainly focused on benzene induced toxicity on rat pancreatic islets with respect to oxidative damage, insulin secretion and glucokinase (GK) activity. Benzene was dissolved in corn oil and administered orally at doses 200, 400 and 800mg/kg/day, for 4 weeks. In rats, benzene significantly raised the concentration of plasma insulin. Also the effect of benzene on the release of glucose-induced insulin was pronounced in isolated islets. Benzene caused oxidative DNA damage and lipid peroxidation, and also reduced the cell viability and total thiols groups, in the islets of exposed rats. In conclusion, the current study revealed that pancreatic glucose metabolism is susceptible to benzene toxicity and the resultant oxidative stress could lead to functional abnormalities in the pancreas.
苯（C6H6）是一种用于石化和众多其他行业的有机化合物。它作为一种化学污染物大量释放到我们的环境中，导致广泛的人类暴露。本研究主要集中在苯对大鼠胰岛的毒性作用，涉及氧化损伤、胰岛素分泌和葡萄糖激酶（GK）活性。苯溶解在玉米油中，以 200、400 和 800mg/kg/天的剂量口服给药，持续 4 周。在大鼠中，苯显著提高了血浆胰岛素的浓度。此外，苯对分离胰岛中葡萄糖诱导的胰岛素释放的影响也很明显。苯引起胰岛内的氧化 DNA 损伤和脂质过氧化，还降低了暴露大鼠胰岛的细胞活力和总巯基基团。总之，本研究表明，胰腺葡萄糖代谢易受苯毒性的影响，由此产生的氧化应激可能导致胰腺功能异常。
