ROMK (Kir1.1) pharmacology comes of age.
作者信息
Kharade Sujay V, Swale Daniel R, Denton Jerod S
机构信息
a Department of Anesthesiology ; Vanderbilt University Medical Center ; Nashville , TN USA.
出版信息
Channels (Austin). 2015;9(3):119-20. doi: 10.1080/19336950.2015.1046733.
Abstract
摘要
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本文引用的文献
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Computational and functional analyses of a small-molecule binding site in ROMK.
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Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis.
J Pharmacol Exp Ther. 2014 Jan;348(1):153-64. doi: 10.1124/jpet.113.208603. Epub 2013 Oct 18.
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Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.
Mol Pharmacol. 2011 Jan;79(1):42-50. doi: 10.1124/mol.110.066928. Epub 2010 Oct 6.
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High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1.
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Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK.
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