Brkljača Robert, Gӧker Emrehan Semih, Urban Sylvia
School of Applied Sciences (Discipline of Chemistry), Health Innovations Research Institute (HIRi), RMIT University, GPO Box 2476V Melbourne, Victoria 3001, Australia.
Mar Drugs. 2015 Apr 30;13(5):2714-31. doi: 10.3390/md13052714.
Dereplication and chemotaxonomic studies of six marine algae of the Ochrophyta and one of the Rhodophyta phyla resulted in the detection of 22 separate compounds. All 16 secondary metabolites, including four new compounds (16-19), could be rapidly dereplicated using HPLC-NMR and HPLC-MS methodologies in conjunction with the MarinLit database. This study highlights the advantages of using NMR data (acquired via HPLC-NMR) for database searching and for the overall dereplication of natural products.
对褐藻门的六种海洋藻类和红藻门的一种藻类进行的去重复和化学分类学研究，检测到了22种不同的化合物。利用HPLC-NMR和HPLC-MS方法结合MarinLit数据库，所有16种次生代谢产物，包括四种新化合物（16 - 19），都能快速去重复。本研究突出了利用（通过HPLC-NMR获得的）NMR数据进行数据库搜索和天然产物整体去重复的优势。
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