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低剂量脊髓麻醉下肛肠手术中截石位与折刀位对经阻抗心动图评估的血流动力学参数的影响:一项随机对照试验

Lithotomy versus jack-knife position on haemodynamic parameters assessed by impedance cardiography during anorectal surgery under low dose spinal anaesthesia: a randomized controlled trial.

作者信息

Borodiciene Jurgita, Gudaityte Jurate, Macas Andrius

机构信息

Department of Anaesthesiology, Lithuanian University of Health Sciences, Eiveniu str. 2, LT-50009, Kaunas, Lithuania.

出版信息

BMC Anesthesiol. 2015 May 6;15:74. doi: 10.1186/s12871-015-0055-3.

Abstract

BACKGROUND

Although the prone position providing better exposure for anorectal surgery is required it can cause a reduction of cardiac output and cardiac index. The goal was to compare haemodynamic changes assessed by impedance cardiography during anorectal surgery under low-dose spinal anaesthesia in lithotomy and jack-knife position.

METHODS

The prospective randomized controlled study included 104, ASA I-II adult patients admitted for elective minor anorectal surgery, assigned to be performed in lithotomy (groupL, n = 52) or jack-knife position (groupJ, n = 52). After arrival to operating room the standard monitoring, impedance cardiography device was connected to the patient, and the following variables were recorded: cardiac output, cardiac index, systemic vascular resistance, stroke index at times of arrival to operating room, placement for, start and end of surgery and placement to bed. Spinal block was made in the sitting position with 4 mg of 0.5% hyperbaric bupivacaine and 10 μg of Fentanyl injected over 2 min. Comparison was based on haemodynamic changes between and inside groups over time. Student's t, chi square tests were used for statistical analysis with p < 0.05 regarded as statistically significant.

RESULTS

The reduction of cardiac output was statistically significant after placement of the patient into the prone position: from baseline 7.4+/-1.6 to 4.9+/-1.2 after placement for and 4.7+/-1.2 at the start and end of surgery (mean +/-SD l/min). The difference of cardiac output between groups was 2.0 l/min after positioning for and the start of surgery and 1.5 l/min at the end of surgery (p < 0.05). Mean cardiac index reduced from baseline 3.9+/-0.8 to 2.6+/-0.7 and 2.4+/-0.6 (mean+/-SD l/min/m(2)) in groupJ and between groups: by 1.0 l/min/m(2) after placement for, 1.1 at the start and 0.8 at the end of surgery (p < 0.05). Systemic vascular resistance increased from baseline 1080+/-338 to 1483+/-479 after placement for, 1523+/-481 at the start and 1525+/-545 at the end of surgery in groupJ (mean+/-SD dynes/sec/cm(-5), p < 0.05).

CONCLUSIONS

According to impedance cardiography, jack-knife position after low-dose spinal anaesthesia produces transitory, but statistically significant reduction of cardiac output and cardiac index with increase of systemic vascular resistance, compared to insignificant changes in lithotomy position.

TRIAL REGISTRATION

Clinical Trials NCT02115178.

摘要

背景

尽管俯卧位能为肛肠手术提供更好的视野,但会导致心输出量和心脏指数降低。本研究旨在比较低剂量脊髓麻醉下截石位和折刀位肛肠手术期间通过阻抗心动图评估的血流动力学变化。

方法

这项前瞻性随机对照研究纳入了104例美国麻醉医师协会(ASA)I-II级择期接受小型肛肠手术的成年患者,随机分为截石位组(L组,n = 52)和折刀位组(J组,n = 52)。患者进入手术室后,连接标准监测设备和阻抗心动图装置,记录以下变量:到达手术室时、摆放体位时、手术开始和结束时以及安置回病床时的心输出量、心脏指数、全身血管阻力、每搏指数。患者取坐位,于2分钟内注入4mg 0.5%的高压布比卡因和10μg芬太尼进行脊髓阻滞。基于组间和组内随时间的血流动力学变化进行比较。采用学生t检验和卡方检验进行统计分析,p < 0.05被视为具有统计学意义。

结果

患者摆为俯卧位后,心输出量显著降低:从基线的7.4±1.6降至摆放体位后的4.9±1.2以及手术开始和结束时的4.7±1.2(平均值±标准差,l/min)。组间心输出量差异在摆放体位后和手术开始时为2.0 l/min,手术结束时为1.5 l/min(p < 0.05)。J组平均心脏指数从基线的3.9±0.8降至2.6±0.7和2.4±0.6(平均值±标准差,l/min/m²),组间比较:摆放体位后降低1.0 l/min/m²,手术开始时降低1.1,手术结束时降低0.8(p < 0.05)。J组全身血管阻力从基线的1080±338增加到摆放体位后的1483±479,手术开始时为1523±481,手术结束时为1525±545(平均值±标准差,达因/秒/厘米⁻⁵,p < 0.05)。

结论

根据阻抗心动图,与截石位无明显变化相比,低剂量脊髓麻醉后折刀位会导致心输出量和心脏指数短暂但有统计学意义的降低,同时全身血管阻力增加。

试验注册

临床试验编号NCT02115178 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/345f/4429455/2aaeccc224a9/12871_2015_55_Fig1_HTML.jpg

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