Pierot Laurent, Derdeyn Colin
From the Department of Neuroradiology, Hôpital Maison-Blanche, Reims, France (L.P.); and Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (C.D.).
Stroke. 2015 Jun;46(6):1440-6. doi: 10.1161/STROKEAHA.115.008416. Epub 2015 May 5.
Three recently published trials have conclusively proven the benefit of mechanical endovascular thrombectomy over best medical therapy for patients with acute ischemic stroke and large vessel occlusion. These trials shared some features and differed in others. These similarities and differences in trial design and execution affect the conclusions and recommendations that can be made from the data. We will examine the implications of these studies for neurointerventionists, both for current practice and for future studies. In particular, we will focus on procedural details such as patient selection, devices, adjunctive therapies, treatment time windows, and performance metrics.
最近发表的三项试验已确凿证明，对于急性缺血性中风和大血管闭塞患者，机械血管内血栓切除术优于最佳药物治疗。这些试验有一些共同特征，也有一些不同之处。试验设计和实施中的这些异同影响着从数据中得出的结论和建议。我们将研究这些研究对神经介入医生的影响，包括对当前实践和未来研究的影响。特别是，我们将关注诸如患者选择、设备、辅助治疗、治疗时间窗和性能指标等程序细节。
