Cao Renhai, Ji Hong, Yang Yunlong, Cao Yihai
Department of Microbiology; Tumor and Cell Biology; Karolinska Institute ; Stockholm, Sweden.
Department of Microbiology; Tumor and Cell Biology; Karolinska Institute ; Stockholm, Sweden ; Department of Medicine and Health Sciences; Linköping University ; Linköping, Sweden ; Department of Cardiovascular Sciences; University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Unit; Glenfield Hospital ; Leicester, UK.
Oncoimmunology. 2015 Jan 22;4(3):e989777. doi: 10.4161/2162402X.2014.989777. eCollection 2015 Mar.
Although inflammation and metastasis are two well-known hallmarks of malignant disease, the relationship between inflammation and lymphatic metastasis is an unexplored research area. We recently elucidated a sophisticated mechanism by which TNFα-induced tumor inflammation conscripts macrophage-mediated VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis.