Dajon Marion, Iribarren Kristina, Cremer Isabelle
Institut National de la Santé et de la Recherche Médicale (INSERM); UMRS1138; Centre de Recherche des Cordeliers ; Paris, France ; Université Pierre et Marie Curie-Paris 6; UMRS1138 ; Paris France ; Université Paris Descartes; UMRS1138 ; Paris, France.
Oncoimmunology. 2015 Jan 9;4(3):e991615. doi: 10.4161/2162402X.2014.991615. eCollection 2015 Mar.
Toll-like receptor 7 (TLR7) agonists are under investigation for their ability to enhance antitumor immune responses. However, these agonists can also stimulate TLR7-expressing tumor cells. High TLR7 expression in the primary tumor confers poor clinical outcome and resistance to chemotherapy in lung cancer patients. This protumorigenic effect of TLR7 has been validated in murine models of lung carcinoma.
Toll样受体7(TLR7)激动剂因其增强抗肿瘤免疫反应的能力而正在接受研究。然而,这些激动剂也能刺激表达TLR7的肿瘤细胞。原发性肿瘤中TLR7的高表达会导致肺癌患者临床预后不良和对化疗产生耐药性。TLR7的这种促肿瘤作用已在小鼠肺癌模型中得到验证。