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Dual roles of TLR7 in the lung cancer microenvironment.
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Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8.
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Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance.
J Clin Invest. 2010 Apr;120(4):1285-97. doi: 10.1172/JCI36551. Epub 2010 Mar 8.
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The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy.
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Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer.
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TLR7 promotes tumor progression, chemotherapy resistance, and poor clinical outcomes in non-small cell lung cancer.
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Cancer immunotherapeutic potential of novel small molecule TLR7 and TLR8 agonists.
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Retroelement co-option disrupts the cancer transcriptional programme.
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本文引用的文献

1
TLR7 promotes tumor progression, chemotherapy resistance, and poor clinical outcomes in non-small cell lung cancer.
Cancer Res. 2014 Sep 15;74(18):5008-18. doi: 10.1158/0008-5472.CAN-13-2698. Epub 2014 Jul 29.
2
Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma.
Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
3
Tumor promotion by intratumoral plasmacytoid dendritic cells is reversed by TLR7 ligand treatment.
Cancer Res. 2013 Aug 1;73(15):4629-40. doi: 10.1158/0008-5472.CAN-12-3058. Epub 2013 May 30.
4
Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans.
J Clin Invest. 2012 Nov;122(11):4118-29. doi: 10.1172/JCI63606.
7
Immunomodulation by imiquimod in patients with high-risk primary melanoma.
J Invest Dermatol. 2012 Jan;132(1):163-9. doi: 10.1038/jid.2011.247. Epub 2011 Aug 18.
8
Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8.
Mol Cancer Ther. 2010 Jun;9(6):1788-97. doi: 10.1158/1535-7163.MCT-09-1198. Epub 2010 Jun 1.
9
Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance.
J Clin Invest. 2010 Apr;120(4):1285-97. doi: 10.1172/JCI36551. Epub 2010 Mar 8.
10
TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer.
Cancer Res. 2006 Apr 1;66(7):3859-68. doi: 10.1158/0008-5472.CAN-05-3948.

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