Gil-Ramírez Guzmán, Leigh David A, Stephens Alexander J
School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL (UK) http://www.catenane.net.
Angew Chem Int Ed Engl. 2015 May 18;54(21):6110-50. doi: 10.1002/anie.201411619. Epub 2015 May 7.
Half a century after Schill and Lüttringhaus carried out the first directed synthesis of a [2]catenane, a plethora of strategies now exist for the construction of molecular Hopf links (singly interlocked rings), the simplest type of catenane. The precision and effectiveness with which suitable templates and/or noncovalent interactions can arrange building blocks has also enabled the synthesis of intricate and often beautiful higher order interlocked systems, including Solomon links, Borromean rings, and a Star of David catenane. This Review outlines the diverse strategies that exist for synthesizing catenanes in the 21st century and examines their emerging applications and the challenges that still exist for the synthesis of more complex topologies.
在席尔（Schill）和吕特林豪斯（Lüttringhaus）首次进行[2]连环烷的定向合成半个世纪后，现在已有大量策略可用于构建分子霍普夫链环（单互锁环），这是最简单的一种连环烷。合适的模板和/或非共价相互作用排列构建单元的精确性和有效性，也使得合成复杂且通常很美观的高阶互锁体系成为可能，包括所罗门链环、博罗梅安环和大卫之星连环烷。本综述概述了21世纪存在的用于合成连环烷的各种策略，并探讨了它们新出现的应用以及合成更复杂拓扑结构时仍然存在的挑战。
