通过与吡唑衍生物进行催化不对称开环反应实现2,3-环氧-3-芳基酮的动力学拆分
Kinetic resolution of 2,3-epoxy 3-aryl ketones via catalytic asymmetric ring-opening with pyrazole derivatives.
作者信息
Huang Tianyu, Lin Lili, Hu Xiaolei, Zheng Jianfeng, Liu Xiaohua, Feng Xiaoming
机构信息
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
出版信息
Chem Commun (Camb). 2015 Jul 21;51(57):11374-7. doi: 10.1039/c5cc02179k.
PMID:25959622
Abstract
A highly efficient catalytic kinetic resolution of 2,3-epoxy 3-aryl ketones via asymmetric ring-opening with pyrazole derivatives has been achieved by using a chiral N,N'-dioxide-Sc(III) complex as the catalyst. A wide variety of substrates were readily scoped, and the selectivity factors obtained were excellent (up to >300).
摘要
通过使用手性N,N'-二氧化物- Sc(III)配合物作为催化剂，实现了2,3-环氧-3-芳基酮与吡唑衍生物的不对称开环高效催化动力学拆分。研究了多种底物，获得的选择性因子优异（高达>300）。
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