Changes in Markers of Ovarian Reserve After Laparoscopic Ovarian Cystectomy.

STUDY OBJECTIVE

This study was conducted to determine the changes in ovarian reserve markers after laparoscopic ovarian cystectomy (LOC).

DESIGN

Prospective cohort study (Canadian Task Force classification II-2).

SETTING

University teaching hospital.

PATIENTS

Fifty 50 patients who underwent LOC were prospectively examined to determine the changes in serum markers of ovarian reserve, starting from 1 month before and 3 months after consecutive operations.

INTERVENTIONS

Changes in serum markers were compared between the following groups: endometrioma cysts (n = 26) versus nonendometrioma cysts (n = 24), unilateral cystectomy (n = 38) versus bilateral cystectomy (n = 12), and bilateral endometrioma extirpation (n = 10) versus other cystectomy operations (n = 40).

MEASUREMENTS AND MAIN RESULTS

A significant change was noticed between the preoperative and postoperative antimüllerian hormone (AMH) levels (2.67 ± 2.67 ng/mL vs 1.84 ± 1.72 ng/mL, p < .0001). Serum AMH levels were found to be significantly decreased in endometrioma (p = .002), nonendometrioma (p = .019), unilateral cystectomy (p = .001), bilateral cystectomy (p = .005), bilateral endometrioma (p = .011), and cysts other than bilateral endometrioma (p = .000) groups.

CONCLUSION

The ovarian reserve was found to be diminished after LOC regardless of the presence of endometrioma that could be distinguishable by serum AMH levels.