Quintero Celso, Valderrama Mauricio, Becerra Alexandra, Daniliuc Constantin G, Rojas Rene S
Departamento de Química Inorgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Santiago-22, Chile.
Org Biomol Chem. 2015 Jun 14;13(22):6183-93. doi: 10.1039/c5ob00444f.
An efficient one-step method to access 4(3H)quinazolinimines by reaction of phenylchloroimines with 2-aminobenzonitrile is described. The reaction of (E)-N-(2-cyanophenyl)benzimidoyl chloride with substituted anilines that yields a number of their corresponding C2, N3-substituted quinazoliniminium chlorides or neutral products is also reported. These methods provide direct and flexible access to diverse substituted iminoquinazolines substituted at the C2, N3-positions. All the new compounds were fully characterized and six examples are given with their single-crystal X-ray structure.
描述了一种通过苯基氯亚胺与2-氨基苯甲腈反应高效一步合成4(3H)喹唑啉亚胺的方法。还报道了(E)-N-(2-氰基苯基)苯甲酰氯与取代苯胺的反应，该反应生成了许多相应的C2、N3-取代的喹唑啉亚胺氯化物或中性产物。这些方法为直接灵活地合成在C2、N3位被取代的各种取代亚氨基喹唑啉提供了途径。所有新化合物均得到了充分表征，并给出了六个具有单晶X射线结构的实例。
