儿童长期使用哌拉西林-他唑巴坦相关的发热及可逆性实验室检查异常
Fever and Reversible Laboratory Abnormalities Associated with Prolonged Use of Piperacillin-Tazobactam in Children.
作者信息
Patel Aesha, Mao Kuo-Rei, McNeil J Chase, Kaplan Sheldon L, Vallejo Jesus G
机构信息
From the *Department of Pediatrics, Infectious Diseases Section, Baylor College of Medicine, Houston, Texas; and †Department of Pharmacy, Texas Children's Hospital, Houston, Texas.
出版信息
Pediatr Infect Dis J. 2015 Aug;34(8):849-50. doi: 10.1097/INF.0000000000000748.
Piperacillin-tazobactam is used frequently in pediatric patients with complicated appendicitis and other intra-abdominal infections. We report 10 pediatric patients who developed a piperacillin-tazobactam-associated adverse reaction characterized by fever, rash, hematologic abnormalities and transaminitis. Physicians should be aware of this entity in patients treated with a prolonged course of piperacillin-tazobactam. Prompt identification can obviate unnecessary diagnostic testing and treatment.
哌拉西林-他唑巴坦常用于患有复杂性阑尾炎和其他腹腔内感染的儿科患者。我们报告了10例儿科患者，他们出现了以发热、皮疹、血液学异常和转氨酶升高为特征的与哌拉西林-他唑巴坦相关的不良反应。医生在使用哌拉西林-他唑巴坦进行长期治疗的患者中应注意到这种情况。及时识别可避免不必要的诊断检查和治疗。
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