DNA甲基化：记忆的动态与稳定调控
DNA methylation: dynamic and stable regulation of memory.
作者信息
Vaissière Thomas, Miller Courtney A
出版信息
Biomol Concepts. 2011 Dec 1;2(6):459-67. doi: 10.1515/BMC.2011.046.
Epigenetic mechanisms have emerged as a central process in learning and memory. Histone modifications and DNA methy-lation are epigenetic events that can mediate gene transcription. Interesting features of these epigenetic changes are their transient and long lasting potential. Recent advances in neuroscience suggest that DNA methylation is both dynamic and stable, mediating the formation and maintenance of memory. In this review, we will further illustrate the recent hypothesis that DNA methylation participates in the transcriptional regulation necessary for memory.
表观遗传机制已成为学习和记忆中的核心过程。组蛋白修饰和DNA甲基化是可介导基因转录的表观遗传事件。这些表观遗传变化的有趣特征在于其具有短暂和持久的潜力。神经科学的最新进展表明，DNA甲基化既具有动态性又具有稳定性，可介导记忆的形成和维持。在本综述中，我们将进一步阐述最近的假说，即DNA甲基化参与记忆所需的转录调控。
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