Chen Jing, Wang Wei, Li Xiaoguang, Xu Jie
Department of Infectious Disease, Peking University Third Hospital, 100191, Beijing, China.
BMC Gastroenterol. 2015 May 12;15:58. doi: 10.1186/s12876-015-0286-2.
Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese population by meta-analysis.
Search the relevant published papers and perform meta-analysis respectively on IL28B (rs12979860 and rs8099917) in Asian population and Chinese population under an additive genetic model by STATA11.0.
The pooled odds ratios (OR) of rs12979860 are 0.79 (95% CI, 0.53-1.18; P = 0.25, I(2) = 63.2%) and 1.62 (95% CI, 1.04-2.51; P = 0.033, I(2) = 54.3%) respectively in Asian population and Chinese population analysis. The pooled OR of rs8099917 are 1.05 (95% CI, 0.93-1.19; P = 0.44, I(2) = 43.3%) and 0.97 (95% CI, 0.84-1.23; P = 0.726, I(2) = 15.6%) respectively in Asian population and Chinese population analysis.
Our study demonstrated that T allele of rs12979680 can increase the risk of HBV infection in Chinese population but not Asian population under an additive genetic model. There is no association between rs8099917 and HBV infection in Chinese population and Asian population.
几项针对白细胞介素28B基因（IL28B）中两个单核苷酸多态性（SNP，rs12979860和rs8099917）的小样本关联研究结果不一致。因此，在本研究中，我们旨在通过荟萃分析评估这两个SNP与亚洲人群尤其是中国人群中乙型肝炎病毒（HBV）感染易感性之间的关联。
检索相关已发表论文，并使用STATA11.0软件，分别在亚洲人群和中国人群中，在加性遗传模型下对IL28B基因（rs12979860和rs8099917）进行荟萃分析。
在亚洲人群和中国人群分析中，rs12979860的合并比值比（OR）分别为0.79（95%可信区间，0.53 - 1.18；P = 0.25，I² = 63.2%）和1.62（95%可信区间，1.04 - 2.51；P = 0.033，I² = 54.3%）。在亚洲人群和中国人群分析中，rs8099917的合并OR分别为1.05（95%可信区间，0.93 - 1.19；P = 0.44，I² = 43.3%）和0.97（95%可信区间，0.84 - 1.23；P = 0.726，I² = 15.6%）。
我们的研究表明，在加性遗传模型下，rs12979６80的T等位基因可增加中国人群而非亚洲人群的HBV感染风险。rs8099917与中国人群和亚洲人群的HBV感染之间无关联。
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