Macedo I C, Rozisky J R, Oliveira C, Oliveira C M, Laste G, Nonose Y, Santos V S, Marques P R, Ribeiro M F M, Caumo W, Torres I L S
Pain Pharmacology and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Graduate Program in Biological Sciences - Physiology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Animal Experimentation Unit and Graduate Research Group, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil.
Pain Pharmacology and Neuromodulation Laboratory: Animal Models, Department of Pharmacology, Universidade Federal do Rio Grande do Sul Institute of Basic Health Sciences, Porto Alegre, RS 90050-170, Brazil; Animal Experimentation Unit and Graduate Research Group, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil; Graduate Program in Medical Sciences - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil.
Neuropeptides. 2015 Jun;51:75-81. doi: 10.1016/j.npep.2015.01.002. Epub 2015 Feb 12.
Chronic stress, whether associated with obesity or not, leads to different neuroendocrine and psychological changes. Obesity or being overweight has become one of the most serious worldwide public health problems. Additionally, it is related to a substantial increase in daily energy intake, which results in substituting nutritionally adequate meals for snacks. This metabolic disorder can lead to morbidity, mortality, and reduced quality of life. On the other hand, brain-derived neurotrophic factor (BDNF) is widely expressed in all brain regions, particularly in the hypothalamus, where it has important effects on neuroprotection, synaptic plasticity, mammalian food intake-behavior, and energy metabolism. BDNF is involved in many activities modulated by the hypothalamic-pituitary-adrenal (HPA) axis. Therefore, this study aims to evaluate the effect of obesity associated with chronic stress on the BDNF central levels of rats. Obesity was controlled by analyzing the animals' caloric intake and changes in body weight. As a stress parameter, we analyzed the relative adrenal gland weight. We found that exposure to chronic restraint stress during 12 weeks increases the adrenal gland weight, decreases the BDNF levels in the hippocampus and is associated with a decrease in the calorie and sucrose intake, characterizing anhedonia. These effects can be related stress, a phenomenon that induces depression-like behavior. On the other hand, the rats that received the hypercaloric diet had an increase in calorie intake and became obese, which was associated with a decrease in hypothalamus BDNF levels.
慢性应激，无论是否与肥胖相关，都会导致不同的神经内分泌和心理变化。肥胖或超重已成为全球最严重的公共卫生问题之一。此外，它与每日能量摄入量的大幅增加有关，这导致用营养充足的正餐替代零食。这种代谢紊乱会导致发病率、死亡率上升以及生活质量下降。另一方面，脑源性神经营养因子（BDNF）在所有脑区广泛表达，特别是在下丘脑，它在神经保护、突触可塑性、哺乳动物的食物摄入行为和能量代谢方面具有重要作用。BDNF参与许多由下丘脑 - 垂体 - 肾上腺（HPA）轴调节的活动。因此，本研究旨在评估与慢性应激相关的肥胖对大鼠BDNF中枢水平的影响。通过分析动物的热量摄入和体重变化来控制肥胖。作为应激参数，我们分析了肾上腺相对重量。我们发现，在12周内暴露于慢性束缚应激会增加肾上腺重量，降低海马体中的BDNF水平，并与热量和蔗糖摄入量减少相关，表现为快感缺失。这些影响可能与应激有关，应激是一种诱发类似抑郁行为的现象。另一方面，接受高热量饮食的大鼠热量摄入量增加并变得肥胖，这与下丘脑BDNF水平降低有关。
