Tolisano Anthony M, Klem Christopher, Lustik Michael B, Sniezek Joseph C, Golden J Blake
Department of Otolaryngology, Tripler Army Medical Center, Honolulu, Hawaii.
Department of Clinical Investigations, Tripler Army Medical Center, Honolulu, Hawaii.
Head Neck. 2016 Apr;38 Suppl 1:E890-4. doi: 10.1002/hed.24121. Epub 2015 Jul 15.
The purpose of this study was to characterize the timing, histology, and behavior of second primary thyroid carcinoma (SPTC) developing after a diagnosis of head and neck squamous cell carcinoma (HNSCC).
We conducted a retrospective review of the Surveillance, Epidemiology, and End Results (SEER) 9 database.
Patients with HNSCC who develop SPTC die 1.6 times sooner than those without SPTC. This effect is only seen if SPTC presents >6 months after diagnosis of HNSCC. Models were adjusted for age, sex, year of diagnosis, and location of HNSCC. There was no effect of prior radiation therapy on either mortality rates or time to development of thyroid cancer in patients with SPTC. The type of thyroid carcinoma that developed was similar between cohorts.
The development of SPTC in patients with HNSCC results in decreased overall length of survival. © 2015 Wiley Periodicals, Inc. Head Neck 38: E890-E894, 2016.
本研究的目的是描述在头颈部鳞状细胞癌（HNSCC）诊断后发生的第二原发性甲状腺癌（SPTC）的发生时间、组织学特征及行为。
我们对监测、流行病学和最终结果（SEER）9数据库进行了回顾性研究。
发生SPTC的HNSCC患者的死亡时间比未发生SPTC的患者早1.6倍。仅当SPTC在HNSCC诊断6个月后出现时才会出现这种效应。模型根据年龄、性别、诊断年份和HNSCC的位置进行了调整。既往放疗对SPTC患者的死亡率或甲状腺癌发生时间均无影响。各队列中发生的甲状腺癌类型相似。
HNSCC患者发生SPTC会导致总体生存时间缩短。©2015威利期刊公司。《头颈》38:E890-E894，2016年。
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