In vitro differentiation of sperm from male germline stem cell.
作者信息
Zheng P, Zhao X W, Zheng X M, Khalid A, Zhao Q, Zhang G X
机构信息
College of Animal Science and Technology, Northeast Agricultural University, Harbin, China.
College of Animal Science and Technology, Northeast Agricultural University, Harbin, China
出版信息
Genet Mol Res. 2015 Apr 10;14(2):2964-9. doi: 10.4238/2015.April.10.5.
PMID:25966059
Abstract
In this study, we developed a model of sperm in vitro differentiation to study the mechanism of spermatogenesis. We isolated newborn male germ cells for in vitro differentiation. We found that after 4-5 weeks of culture, sperm-like cells were occasionally observed in cell co-culture and the feed-layer. After 1-2 weeks of culture followed by 4-5 weeks of co-culture, sperm-like cells were observed.
摘要
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