对整体基质片剂中iota-卡拉胶溶胀行为的评估。

Evaluation of the swelling behaviour of iota-carrageenan in monolithic matrix tablets.

作者信息

Kelemen András, Buchholcz Gyula, Sovány Tamás, Pintye-Hódi Klára

机构信息

Department of Applied Informatics, University of Szeged, Boldogasszony sgt. 6, H-6725 Szeged, Hungary.

Central Clinical Pharmacy, University of Debrecen, Nagyerdei krt 98, H-4032 Debrecen, Hungary.

出版信息

J Pharm Biomed Anal. 2015 Aug 10;112:85-8. doi: 10.1016/j.jpba.2015.04.025. Epub 2015 Apr 24.

DOI:10.1016/j.jpba.2015.04.025

PMID:25966465

Abstract

The swelling properties of monolithic matrix tablets containing iota-carrageenan were studied at different pH values, with measurements of the swelling force and characterization of the profile of the swelling curve. The swelling force meter was linked to a PC by an RS232 cable and the measured data were evaluated with self-developed software. The monitor displayed the swelling force vs. time curve with the important parameters, which could be fitted with an Analysis menu. In the case of iota-carrageenan matrix tablets, it was concluded that the pH and the pressure did not influence the swelling process, and the first section of the swelling curve could be fitted by the Korsmeyer-Peppas equation.

摘要

研究了含ι-卡拉胶的整体基质片剂在不同pH值下的溶胀特性，测定了溶胀力并对溶胀曲线进行了表征。溶胀力计通过RS232电缆连接到个人计算机，测量数据用自行开发的软件进行评估。监视器显示溶胀力与时间的曲线以及重要参数，可通过分析菜单进行拟合。对于ι-卡拉胶基质片剂，得出pH值和压力不影响溶胀过程的结论，溶胀曲线的第一部分可用Korsmeyer-Peppas方程拟合。