Kinoshita Hiroshi, Tanaka Naoko, Jamal Mostofa, Kumihashi Mitsuru, Takakura Ayaka, Tobiume T, Tsutsui Kunihito, Ameno Kiyoshi
Soud Lek. 2015;60(2):25-7.
We present a fatal case involving poisoning with paroxetine, flunitrazepam, and ethanol, with putrefactive changes. Quantitative toxicological analysis showed that the concentrations of paroxetine and 7-aminoflunitrazepam, a metabolite of flunitrazepam, in the femoral blood were 0.28 µg/ml and 0.17 µg/ml, respectively. We also detected an ethanol level of 2.90 mg/ml and an n-propanol level of 0.10 mg/ml. We concluded that the cause of death was due to the interaction of paroxetine, flunitrazepam, and ethanol. The effects of putrefactive changes should be considered during forensic toxicological evaluation.
我们报告一例涉及帕罗西汀、氟硝西泮和乙醇中毒并伴有腐败变化的死亡病例。定量毒理学分析显示,股静脉血中帕罗西汀和氟硝西泮的代谢产物7-氨基氟硝西泮的浓度分别为0.28μg/ml和0.17μg/ml。我们还检测到乙醇水平为2.90mg/ml,正丙醇水平为0.10mg/ml。我们得出结论,死亡原因是帕罗西汀、氟硝西泮和乙醇的相互作用。在法医毒理学评估中应考虑腐败变化的影响。