温和的芳基硼酸催化的选择性[4 + 3]环加成反应：通向环庚并[b]苯并呋喃和环庚并[b]吲哚的途径。
Mild arylboronic acid catalyzed selective [4 + 3] cycloadditions: access to cyclohepta[b]benzofurans and cyclohepta[b]indoles.
作者信息
Cao Kou-Sen, Bian Hong-Xu, Zheng Wen-Hua
机构信息
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China.
出版信息
Org Biomol Chem. 2015 Jun 21;13(23):6449-52. doi: 10.1039/c5ob00653h. Epub 2015 May 14.
PMID:25971529
Abstract
The first example of arylboronic acid catalyzed [4 + 3] cycloaddition reaction is reported. 3,5-Bis-(trifluoromethyl) phenylboronic acid is shown to be the best catalyst in this reaction. The method has also enabled the preparation of cyclohepta[b]benzofurans and cyclohepta[b]indoles in excellent yields.
摘要
报道了芳基硼酸催化的[4 + 3]环加成反应的首个实例。结果表明，3,5-双（三氟甲基）苯硼酸是该反应中最佳的催化剂。该方法还能以优异的产率制备环庚并[b]苯并呋喃和环庚并[b]吲哚。
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