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[蔡氏被盖腹侧区向海马的投射:应用芬克 - 海默技术对大鼠的研究]

[Projections of the Tsai tegmental ventral area to the hippocampus: a study of the rat using the Fink-Heimer technic].

作者信息

Gasbarri A, Campana E, Pacitti F, Pacitti C

出版信息

Boll Soc Ital Biol Sper. 1989 Jul;65(7):639-45.

PMID:2597418
Abstract

The projection from the ventral tegmental area of Tsai (VTA-A10) to the hippocampal formation was investigated in the rat by means of the Fink-Heimer technique, after VTA destruction by electrolytic lesion or local injection of 6-hydroxydopamine (6-OHDA, 1 micrograms/0.5 microliters). Degenerated fibers are prevalently present in the ventral subiculum and CA1 field. These areas match with the area projecting towards the nucleus accumbens. Thus the dopaminergic meso-cortico-limbic pathway could modulate the HF-striatal projection which represents a link between the limbic and central motor systems.

摘要

通过Fink-Heimer技术,在大鼠中研究了蔡氏腹侧被盖区(VTA-A10)向海马结构的投射,实验方法是用电解损伤或局部注射6-羟基多巴胺(6-OHDA,1微克/0.5微升)破坏VTA。变性纤维主要存在于腹侧下托和CA1区。这些区域与投射到伏隔核的区域相匹配。因此,多巴胺能中脑-皮质-边缘通路可能调节海马-纹状体投射,该投射代表了边缘系统和中枢运动系统之间的联系。

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