不变自然杀伤T细胞及其配体：聚焦于多发性硬化症。
Invariant natural killer T cells and their ligands: focus on multiple sclerosis.
作者信息
O'Keeffe Joan, Podbielska Maria, Hogan Edward L
机构信息
Department of Life and Physical Sciences, School of Science, Galway-Mayo Institute of Technology, Galway, Ireland.
Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, GA, USA.
出版信息
Immunology. 2015 Aug;145(4):468-75. doi: 10.1111/imm.12481. Epub 2015 Jun 25.
Abstract
Invariant natural killer T (iNKT) cells are an innate population of T cells identified by the expression of an invariant T-cell receptor and reactivity to lipid-based antigens complexed with CD1d. They account for a small percentage of lymphocytes, but are extremely potent and play central roles in immunity to infection, in some cancers, and in autoimmunity. The list of relevant stimulatory lipids and glycolipid antigens now includes a range of endogenous self-antigens including the myelin-derived acetylated galactosylceramides. Recent progress in studies to identify the nature of lipid recognition for iNKT cells in autoimmune diseases like multiple sclerosis is likely to foster the development of therapeutic strategies aimed at harnessing iNKT cell activity.
摘要
不变自然杀伤T（iNKT）细胞是一类先天性T细胞群体，通过不变T细胞受体的表达以及对与CD1d复合的基于脂质的抗原的反应性来识别。它们在淋巴细胞中所占比例很小，但极其强大，在抗感染免疫、某些癌症以及自身免疫中发挥核心作用。现在，相关的刺激性脂质和糖脂抗原列表包括一系列内源性自身抗原，如髓鞘衍生的乙酰化半乳糖神经酰胺。在诸如多发性硬化症等自身免疫性疾病中，鉴定iNKT细胞脂质识别性质的研究取得的最新进展，可能会促进旨在利用iNKT细胞活性的治疗策略的发展。
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J Clin Cell Immunol. 2013 Jun;4(3). doi: 10.4172/2155-9899.1000144.
2
Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice.视黄酸对I型自然杀伤T细胞的抑制作用，或在硫苷脂介导的II型自然杀伤T细胞激活后，可减轻小鼠的酒精性肝病。
Hepatology. 2015 Apr;61(4):1357-69. doi: 10.1002/hep.27632. Epub 2015 Feb 23.
3
The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides.自然杀伤T细胞内源性配体的鉴定揭示了哺乳动物α-连接糖基神经酰胺的存在。
Immunity. 2014 Oct 16;41(4):543-54. doi: 10.1016/j.immuni.2014.08.017.
4
The role of invariant natural killer T cells in microbial immunity.不变自然杀伤 T 细胞在微生物免疫中的作用。
J Infect Chemother. 2013 Aug;19(4):560-70. doi: 10.1007/s10156-013-0638-1. Epub 2013 Jul 12.
5
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J Neuroimmunol. 2013 Jun 15;259(1-2):1-7. doi: 10.1016/j.jneuroim.2013.02.020. Epub 2013 Mar 26.
6
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.不变自然杀伤 T 细胞：与多种效应功能相关的先天激活方案。
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7
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Nat Rev Immunol. 2012 Dec;12(12):845-57. doi: 10.1038/nri3328. Epub 2012 Nov 16.
8
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J Clin Invest. 2012 Nov;122(11):3943-54. doi: 10.1172/JCI62267. Epub 2012 Oct 15.
9
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Trends Immunol. 2013 Feb;34(2):50-8. doi: 10.1016/j.it.2012.08.009. Epub 2012 Sep 25.
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