Rowe Steven P, Vicente Esther, Anizan Nadège, Wang Hao, Leal Jeffrey P, Lodge Martin A, Frey Eric C, Wahl Richard L
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
J Nucl Med. 2015 Jul;56(7):985-8. doi: 10.2967/jnumed.115.155358. Epub 2015 May 14.
With an increasing emphasis on quantitation of SPECT imaging and its use in dosimetry to guide therapies, it is desirable to understand the repeatability in normal-organ SPECT uptake values (SPECT-UVs). We investigated the variability of normal abdominal organ uptake in repeated (111)In-pentetreotide SPECT studies.
Nine patients with multiple (111)In-pentetreotide SPECT/CT studies for clinical purposes were evaluated. Volumes of interest were drawn for the abdominal organs and applied to SPECT-UVs. The variability of those values was assessed.
The average SPECT-UV for the liver (1.7 ± 0.6) was much lower than for the kidneys (right, 8.0 ± 2.4; left, 7.5 ± 1.7). Interpatient and intrapatient variability was similar (intraclass correlation coefficients, 0.40-0.59) for all organs. The average coefficients of variation for each organ for each patient were obtained and averaged across all patients (0.26 for liver, 0.22 for right kidney, and 0.20 for left kidney). The coefficients of variation for the organs across all scans were 0.33 (liver), 0.30 (right kidney), and 0.22 (left kidney).
Variability across all patients and all scans for the liver was higher than reported with (18)F-FDG PET, though left kidney variability was similar to PET liver variability and left kidney uptake may be able to serve as an internal metric for determining the quantifiability of an (111)In-pentetreotide SPECT study.
随着对单光子发射计算机断层扫描（SPECT）成像定量分析及其在剂量测定中用于指导治疗的重视程度不断提高，了解正常器官SPECT摄取值（SPECT-UVs）的可重复性是很有必要的。我们研究了重复进行的铟-111喷替膦SPECT研究中正常腹部器官摄取的变异性。
评估了9例因临床目的进行多次铟-111喷替膦SPECT/CT研究的患者。为腹部器官绘制感兴趣区，并应用于SPECT-UVs。评估这些值的变异性。
肝脏的平均SPECT-UV（1.7±0.6）远低于肾脏（右侧，8.0±2.4；左侧，7.5±1.7）。所有器官的患者间和患者内变异性相似（组内相关系数，0.40 - 0.59）。获取每位患者每个器官的平均变异系数，并在所有患者中进行平均（肝脏为0.26，右肾为0.22，左肾为0.20）。所有扫描中各器官的变异系数分别为：肝脏0.33、右肾0.30、左肾0.22。
所有患者和所有扫描中肝脏的变异性高于氟-18氟代脱氧葡萄糖（18F-FDG）正电子发射断层扫描（PET）报告的变异性，尽管左肾变异性与PET肝脏变异性相似，且左肾摄取可能能够作为确定铟-111喷替膦SPECT研究可量化性的内部指标。
