Cipolletta Campanile Anna, Malzone Maria Gabriella, Sanna Veronica, Barizzi Jessica, Manna Angela, Gioioso Antonella, De Chiara Annarosaria, Fulciniti Franco
S.S.D. di Citopatologia e S.C. di Anatomia Patologica, Istituto Nazionale Tumori "Fondazione G. Pascale", via Mariano Semmola, 80131, Napoli, Italy.
Endocr Pathol. 2015 Sep;26(3):243-9. doi: 10.1007/s12022-015-9375-6.
Merkel cell carcinoma (MCC) is an uncommon neuroendocrine small cell tumor derived from the transformation of the homonymous cells in the basal layer of the epidermis. MCC has a generally aggressive course, with a high tendency for local recurrence, lymph node involvement, and distant metastasis. Fine needle cytology (FNC) and immunocytochemistry were used as diagnostic procedures for 22 cases of MCC presented at our institute. All cases of MCC were successfully diagnosed on FNC. Among all of the monoclonal antisera used (CD56, CK20, CK MNF116, neuron-specific enolase (NSE), synaptophysin, and chromogranin), NSE and CD56 showed the highest frequency of positivity. The accuracy of the cytological diagnosis was 100% compared to the corresponding previous or subsequent pathological diagnoses. FNC and immunocytochemistry represent excellent and accurate diagnostic methods to distinguish MCC from other small-cell malignant entities.
默克尔细胞癌（MCC）是一种罕见的神经内分泌小细胞肿瘤，由表皮基底层同名细胞转化而来。MCC通常病程侵袭性强，局部复发、淋巴结受累及远处转移倾向高。细针穿刺细胞学检查（FNC）和免疫细胞化学被用作我院收治的22例MCC的诊断方法。所有MCC病例均通过FNC成功诊断。在所有使用的单克隆抗血清（CD56、CK20、CK MNF116、神经元特异性烯醇化酶（NSE）、突触素和嗜铬粒蛋白）中，NSE和CD56显示出最高的阳性频率。与相应的既往或后续病理诊断相比，细胞学诊断的准确率为100%。FNC和免疫细胞化学是区分MCC与其他小细胞恶性实体的优秀且准确的诊断方法。
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