癌抗原125水平可预测慢性阻塞性肺疾病的长期死亡率。
Cancer antigen-125 levels predict long-term mortality in chronic obstructive pulmonary disease.
作者信息
Kaya Hakki, Zorlu Ali, Yucel Hasan, Dogan Omer Tamer, Sarikaya Savas, Aydin Gulay, Kivrak Tarik, Yilmaz Mehmet Birhan
机构信息
Department of Cardiology and.
出版信息
Biomarkers. 2015 Mar;20(2):162-7. doi: 10.3109/1354750X.2015.1045033. Epub 2015 May 19.
BACKGROUND
Cancer antigen-125 (CA-125) might be a useful biomarker to predict long-term mortality in patients with recent exacerbation of chronic obstructive pulmonary disease (COPD).
METHODS
A total of 87 consecutive patients with COPD were evaluated prospectively. Mean age of patients was 68 ± 10 years (55% males, 45% females) with a median follow-up period of 49 months. Optimal cut-off value of CA-125 to predict mortality was found as >93.34 U/ml, with 91% specificity and 40% sensitivity.
RESULTS
After follow-up, 20 out of 87 (23%) experienced cardiovascular death. CA-125 levels were higher among those who died compared to those who survived [55 (12-264) versus 28 (5-245) U/ml, p = 0.013]. In multivariate Cox proportional-hazards model with forward stepwise method, only CA-125 > 93.34 U/ml on admission (HR = 3.713, 95% CI: 1.035-13.323, p = 0.044) remained associated with an increased risk of death.
CONCLUSIONS
For the first time, we demonstrated that CA-125 helps the risk stratification of patients with COPD.
背景
癌抗原125（CA - 125）可能是预测近期慢性阻塞性肺疾病（COPD）急性加重患者长期死亡率的有用生物标志物。
方法
前瞻性评估了连续87例COPD患者。患者的平均年龄为68±10岁（男性55%，女性45%），中位随访期为49个月。发现预测死亡率的CA - 125最佳临界值>93.34 U/ml，特异性为91%，敏感性为40%。
结果
随访后，87例中有20例（23%）发生心血管死亡。死亡患者的CA - 125水平高于存活患者[55（12 - 264）与28（5 - 245）U/ml，p = 0.013]。在采用向前逐步法的多变量Cox比例风险模型中，仅入院时CA - 125>93.34 U/ml（HR = 3.713，95%CI：1.035 - 13.323，p = 需044）与死亡风险增加相关。
结论
我们首次证明CA - 125有助于COPD患者的风险分层。
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