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微创主动脉瓣置换术:长期结果比较

Minimally invasive aortic valve replacement: Comparison of long-term outcomes.

作者信息

Ariyaratnam Priyadharshanan, Loubani Mahmoud, Griffin Steven C

机构信息

Department of Cardiothoracic Surgery, Castle Hill Hospital, Cottingham, UK

Department of Cardiothoracic Surgery, Castle Hill Hospital, Cottingham, UK.

出版信息

Asian Cardiovasc Thorac Ann. 2015 Sep;23(7):814-21. doi: 10.1177/0218492315587606. Epub 2015 May 19.

Abstract

BACKGROUND

Minimally invasive aortic valve replacement tends to be performed in specialist centers. Little data exists with regard to long-term outcomes of the upper hemi-sternotomy technique. We sought to evaluate the short- and long-term outcomes of this procedure in our institution.

METHODS

Data were collected from our cardiac surgical database. We compared the outcomes of all patients who underwent minimally invasive aortic valve replacement with all who underwent conventional aortic valve replacement between July 1999 and December 2013. Propensity-matching analysis was performed to evaluate hospital outcomes.

RESULTS

There were 125 patients who underwent minimally invasive aortic valve replacement and 1446 who had conventional surgery. After propensity score matching, there were no differences in postoperative mortality or complications between the 2 groups. The only significant differences were longer bypass (62.69 ± 10.12 vs. 68.94 ± 14.79 min, p = 0.002) and crossclamp times (45.48 ± 8.08 vs. 52.30 ± 16.29 min, p < 0.001) in conventional surgery. Long-term survival after minimally invasive aortic valve replacement at 2, 6, and 10 years was 88% ± 3.0%, 79% ± 4.0%, and 66% ± 6.0%, respectively. Predictors of long-term survival were age, peripheral vascular disease, and low ejection fraction (p < 0.005).

CONCLUSION

Minimally invasive aortic valve replacement has similar hospital outcomes compared to conventional aortic valve replacement. The operation is quicker and does not confer any significant increase in complications or length of hospital stay. The long-term outcomes are favorable and justify its continued use by specialist surgeons in the United Kingdom.

摘要

背景

微创主动脉瓣置换术往往在专科中心进行。关于上半胸骨切开术技术的长期结果的数据很少。我们试图评估本院该手术的短期和长期结果。

方法

从我们的心脏外科数据库收集数据。我们比较了1999年7月至2013年12月期间所有接受微创主动脉瓣置换术的患者与所有接受传统主动脉瓣置换术的患者的结果。进行倾向匹配分析以评估住院结果。

结果

有125例患者接受了微创主动脉瓣置换术,1446例接受了传统手术。倾向评分匹配后,两组术后死亡率或并发症无差异。唯一显著的差异是传统手术的体外循环时间更长(62.69±10.12 vs. 68.94±14.79分钟,p = 0.002)和主动脉阻断时间更长(45.48±8.08 vs. 52.30±16.29分钟,p < 0.001)。微创主动脉瓣置换术后2年、6年和10年的长期生存率分别为88%±3.0%、79%±4.0%和66%±6.0%。长期生存的预测因素是年龄、外周血管疾病和低射血分数(p < 0.005)。

结论

与传统主动脉瓣置换术相比,微创主动脉瓣置换术的住院结果相似。该手术更快,不会导致并发症或住院时间显著增加。长期结果良好,证明英国专科外科医生继续使用该手术是合理的。

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