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功能值性状的遗传变异、简单性和进化限制

Genetic variation, simplicity, and evolutionary constraints for function-valued traits.

作者信息

Kingsolver Joel G, Heckman Nancy, Zhang Jonathan, Carter Patrick A, Knies Jennifer L, Stinchcombe John R, Meyer Karin

机构信息

Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599.

出版信息

Am Nat. 2015 Jun;185(6):E166-81. doi: 10.1086/681083. Epub 2015 Apr 6.


DOI:10.1086/681083
PMID:25996868
Abstract

Understanding the patterns of genetic variation and constraint for continuous reaction norms, growth trajectories, and other function-valued traits is challenging. We describe and illustrate a recent analytical method, simple basis analysis (SBA), that uses the genetic variance-covariance (G) matrix to identify "simple" directions of genetic variation and genetic constraints that have straightforward biological interpretations. We discuss the parallels between the eigenvectors (principal components) identified by principal components analysis (PCA) and the simple basis (SB) vectors identified by SBA. We apply these methods to estimated G matrices obtained from 10 studies of thermal performance curves and growth curves. Our results suggest that variation in overall size across all ages represented most of the genetic variance in growth curves. In contrast, variation in overall performance across all temperatures represented less than one-third of the genetic variance in thermal performance curves in all cases, and genetic trade-offs between performance at higher versus lower temperatures were often important. The analyses also identify potential genetic constraints on patterns of early and later growth in growth curves. We suggest that SBA can be a useful complement or alternative to PCA for identifying biologically interpretable directions of genetic variation and constraint in function-valued traits.

摘要

理解连续反应规范、生长轨迹及其他函数值性状的遗传变异和限制模式具有挑战性。我们描述并阐释了一种最新的分析方法——简单基分析(SBA),该方法利用遗传方差协方差(G)矩阵来识别具有直接生物学解释的遗传变异和遗传限制的“简单”方向。我们讨论了主成分分析(PCA)所识别的特征向量(主成分)与SBA所识别的简单基(SB)向量之间的相似之处。我们将这些方法应用于从10项关于热性能曲线和生长曲线的研究中获得的估计G矩阵。我们的结果表明,所有年龄段总体大小的变异占生长曲线中大部分遗传方差。相比之下,所有温度下总体性能的变异在所有情况下均占热性能曲线中遗传方差的不到三分之一,并且高温与低温性能之间的遗传权衡通常很重要。这些分析还确定了生长曲线中早期和后期生长模式的潜在遗传限制。我们认为,对于识别函数值性状中具有生物学可解释性的遗传变异和限制方向,SBA可以成为PCA的有用补充或替代方法。

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