Sit Dorothy, Luther James, Buysse Daniel, Dills John L, Eng Heather, Okun Michele, Wisniewski Stephen, Wisner Katherine L
School of Medicine, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Graduate School of Public Health, Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA, USA.
J Psychiatr Res. 2015 Jul-Aug;66-67:95-104. doi: 10.1016/j.jpsychires.2015.04.021. Epub 2015 May 5.
Suicide is one of the leading causes of death in postpartum women. Identifying modifiable factors related to suicide risk in mothers after delivery is a public health priority. Our study aim was to examine associations between suicidal ideation (SI) and plausible risk factors (experience of abuse in childhood or as an adult, sleep disturbance, and anxiety symptoms) in depressed postpartum women.
This secondary analysis included 628 depressed mothers at 4-6 weeks postpartum. Diagnosis was confirmed with the Structured Clinical Interview for DSM-IV. We examined SI from responses to the Edinburgh Postnatal Depression Scale-EPDS item 10; depression levels on the Structured Interview Guide for the Hamilton Depression Rating Scale, Atypical Depression Symptoms (SIGH-ADS); plus sleep disturbance and anxiety levels with subscales from the EPDS and SIGH-ADS items on sleep and anxiety symptoms.
Of the depressed mothers, 496 (79%) 'never' had thoughts of self-harm; 98 (15.6%) 'hardly ever'; and 34 (5.4%) 'sometimes' or 'quite often'. Logistic regression models indicated that having frequent thoughts of self-harm was related to childhood physical abuse (odds ratio-OR = 1.68, 95% CI = 1.00, 2.81); in mothers without childhood physical abuse, having frequent self-harm thoughts was related to sleep disturbance (OR = 1.15, 95% CI = 1.02, 1.29) and anxiety symptoms (OR = 1.11, 95% CI = 1.01, 1.23).
Because women with postpartum depression can present with frequent thoughts of self-harm and a high level of clinical complexity, conducting a detailed safety assessment, that includes evaluation of childhood abuse history and current symptoms of sleep disturbance and anxiety, is a key component in the management of depressed mothers.
自杀是产后女性的主要死因之一。识别与产后母亲自杀风险相关的可改变因素是公共卫生的重点。我们的研究目的是探讨产后抑郁女性的自杀意念(SI)与可能的风险因素(童年或成年期受虐待经历、睡眠障碍和焦虑症状)之间的关联。
这项二次分析纳入了628名产后4至6周的抑郁母亲。通过《精神疾病诊断与统计手册》第四版(DSM-IV)的结构化临床访谈确诊。我们通过爱丁堡产后抑郁量表(EPDS)第10项的回答来检查自杀意念;通过汉密尔顿抑郁量表(HDRS)、非典型抑郁症状结构化访谈指南(SIGH-ADS)来评估抑郁水平;通过EPDS和SIGH-ADS中关于睡眠和焦虑症状的分量表来评估睡眠障碍和焦虑水平。
在抑郁母亲中,496名(79%)“从未”有过自我伤害的想法;98名(15.6%)“几乎没有”;34名(5.4%)“有时”或 “经常”。逻辑回归模型表明,频繁的自我伤害想法与童年身体虐待有关(优势比-OR = 1.68,95%置信区间 = 1.00,2.81);在没有童年身体虐待的母亲中,频繁的自我伤害想法与睡眠障碍(OR = 1.15,95%置信区间 = 1.02,1.29)和焦虑症状(OR = 1.11,95%置信区间 = 1.01,1.23)有关。
由于产后抑郁女性可能会频繁出现自我伤害的想法且临床情况复杂,进行详细的安全评估,包括评估童年虐待史以及当前的睡眠障碍和焦虑症状,是抑郁母亲管理中的关键组成部分。