胎龄、性别和出生后年龄对早产儿尿液生物标志物的影响。
Impact of gestational age, sex, and postnatal age on urine biomarkers in premature neonates.
作者信息
Saeidi Behtash, Koralkar Rajesh, Griffin Russell L, Halloran Brian, Ambalavanan Namasivayam, Askenazi David J
机构信息
Division of Pediatric Nephrology Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Ave S, Lowder 516, Birmingham, AL, 35233, USA.
Department of Epidemiology, University of Alabama at Birmingham, 1665 University Blvd. Ryals Public Health Building Room 220, Birmingham, AL, 35294-0022, USA.
出版信息
Pediatr Nephrol. 2015 Nov;30(11):2037-44. doi: 10.1007/s00467-015-3129-z. Epub 2015 May 23.
BACKGROUND
Urine proteins may help in understanding physiology and diagnosing disease in premature infants. Determining how urine proteins vary by degree of prematurity, sex, and postnatal day is warranted.
METHODS
We performed a prospective cohort study to assess the independent correlation of 14 urine biomarkers (measured on postnatal days 1-4) with gestational age (GA), sex, and postnatal age in 81 premature infants (mean, 1017 g) without acute kidney injury using a random-effects mixed model.
RESULTS
Neutrophil gelatinase-associated lipocalin (NGAL) and vascular endothelial growth factor (VEGF) showed significant associations for sex, GA, and postnatal age. Cystatin C, osteopontin (OPN), and trefoil factor 3 (TFF3) were associated with postnatal age and GA, but not sex. Epithelial growth factor (EGF) and uromodulin were associated with GA only. Clusterin was associated with postnatal age and sex. Albumin was associated with sex only. Beta-2-microglbulin (B2M), osteoactivin, kidney injury molecule -1 (KIM-1), and alpha glutathione S-transferase (αGST) were associated with postnatal age only.
CONCLUSIONS
Postnatal age affects B2M, cystatin C, NGAL, OPN, clusterin, Kim-1, osteoactivin, TFF3, VEGF, αGST. GA affects cystatin C, EGF, NGAL, OPN, UMOD, TFF3, and VEGF. Sex affects albumin, NGAL, and clusterin. Interpretation of urine biomarkers will need to account for these associations.
背景
尿蛋白可能有助于了解早产儿的生理状况并诊断疾病。确定尿蛋白如何随早产程度、性别和出生后天数而变化是很有必要的。
方法
我们进行了一项前瞻性队列研究，使用随机效应混合模型评估81例无急性肾损伤的早产儿（平均体重1017克）出生后1 - 4天测量的14种尿生物标志物与胎龄（GA）、性别和出生后年龄之间的独立相关性。
结果
中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和血管内皮生长因子（VEGF）在性别、胎龄和出生后年龄方面显示出显著相关性。胱抑素C、骨桥蛋白（OPN）和三叶因子3（TFF3）与出生后年龄和胎龄相关，但与性别无关。上皮生长因子（EGF）和尿调节蛋白仅与胎龄相关。簇集蛋白与出生后年龄和性别相关。白蛋白仅与性别相关。β2微球蛋白（B2M）、骨激活素、肾损伤分子-1（KIM-1）和α谷胱甘肽S-转移酶（αGST）仅与出生后年龄相关。
结论
出生后年龄影响B2M、胱抑素C、NGAL、OPN、簇集蛋白、Kim-1、骨激活素、TFF3、VEGF、αGST。胎龄影响胱抑素C、EGF、NGAL、OPN、尿调节蛋白、TFF3和VEGF。性别影响白蛋白、NGAL和簇集蛋白。对尿生物标志物的解读需要考虑这些关联。
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