玫瑰痤疮患者的心血管合并症：来自台湾的全国病例对照研究。

Cardiovascular comorbidities in patients with rosacea: A nationwide case-control study from Taiwan.

机构信息

Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan; Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.

出版信息

J Am Acad Dermatol. 2015 Aug;73(2):249-54. doi: 10.1016/j.jaad.2015.04.028. Epub 2015 May 23.

DOI:10.1016/j.jaad.2015.04.028

PMID:26004520

Abstract

BACKGROUND

Rosacea is a chronic inflammatory skin disease. Inflammation plays a prominent role in atherosclerosis and its complications.

OBJECTIVE

We sought to investigate the associations of rosacea with cardiovascular disease risk factors and cardiovascular diseases from a nationwide population-based database.

METHODS

A total of 33,553 patients with rosacea and 67,106 age- and gender-matched control subjects were identified from the National Health Insurance Research Database in Taiwan from 1997 to 2010. Multivariate logistic regressions were performed to compare the odds of comorbidities between the 2 groups.

RESULTS

Dyslipidemia (odds ratio 1.41; 95% confidence interval 1.36-1.46), coronary artery disease (odds ratio 1.35, 95% confidence interval 1.29-1.41), and hypertension (odds ratio 1.17, 95% confidence interval 1.12-1.21) were significantly associated with rosacea. Coronary artery disease remained independently associated with rosacea after adjustment for hypertension, diabetes mellitus, and dyslipidemia. Male patients with rosacea had higher risks for all comorbidities than female patients with rosacea.

LIMITATIONS

The National Health Insurance Research Database does not contain information regarding rosacea subtypes or disease severity, or laboratory data.

CONCLUSION

Patients with rosacea are more likely to have dyslipidemia and hypertension. They are also at increased risk of coronary artery disease after adjustment for cardiovascular disease risk factors.

摘要

背景

酒渣鼻是一种慢性炎症性皮肤疾病。炎症在动脉粥样硬化及其并发症中起重要作用。

目的

我们试图从一个全国性的基于人群的数据库中研究酒渣鼻与心血管疾病危险因素和心血管疾病的相关性。

方法

我们从台湾的全民健康保险研究数据库中，于 1997 年至 2010 年共确定了 33553 例酒渣鼻患者和 67106 名年龄和性别匹配的对照者。使用多变量逻辑回归比较两组之间伴发疾病的比值比。

结果

血脂异常（比值比 1.41；95%置信区间 1.36-1.46）、冠状动脉疾病（比值比 1.35，95%置信区间 1.29-1.41）和高血压（比值比 1.17，95%置信区间 1.12-1.21）与酒渣鼻显著相关。在调整高血压、糖尿病和血脂异常后，冠状动脉疾病仍与酒渣鼻独立相关。与女性酒渣鼻患者相比，男性酒渣鼻患者发生所有伴发疾病的风险更高。