Kim Sangkyu, Jazwinski S Michal
Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA.
Healthy Aging Res. 2015;4. doi: 10.12715/har.2015.4.26.
Numerous genetic and non-genetic factors contribute to aging. To facilitate the study of these factors, various descriptors of biological aging, including 'successful aging' and 'frailty', have been put forth as integrative functional measures of aging. A separate but related quantitative approach is the 'frailty index', which has been operationalized and frequently used. Various frailty indices have been constructed. Although based on different numbers and types of health variables, frailty indices possess several common properties that make them useful across different studies. We have been using a frailty index termed FI based on 34 health variables. Like other frailty indices, FI increases non-linearly with advancing age and is a better indicator of biological aging than chronological age. FI has a substantial genetic basis. Using FI, we found elevated levels of resting metabolic rate linked to declining health in nonagenarians. Using FI as a quantitative phenotype, we have also found a genomic region on chromosome 12 that is associated with healthy aging and longevity.
众多遗传和非遗传因素导致衰老。为便于研究这些因素，已提出各种生物衰老描述指标，包括“成功衰老”和“衰弱”，作为衰老的综合功能指标。一种独立但相关的定量方法是“衰弱指数”，它已得到应用且经常被使用。已构建了各种衰弱指数。尽管基于不同数量和类型的健康变量，但衰弱指数具有若干共同特性，使其在不同研究中都很有用。我们一直在使用一种基于34个健康变量的衰弱指数，称为FI。与其他衰弱指数一样，FI随年龄增长呈非线性增加，并且是比实际年龄更好的生物衰老指标。FI有 substantial遗传基础。使用FI，我们发现非agenarians中静息代谢率升高与健康状况下降有关。将FI用作定量表型，我们还发现12号染色体上的一个基因组区域与健康衰老和长寿相关。
