Jia Yujie, Tong Yu, Min Lianqiu
Neurol Res. 2015 Aug;37(8):683-7. doi: 10.1179/1743132815Y.0000000054. Epub 2015 May 25.
The objective of this study is to investigate the significance of functional GRP78 polymorphisms in predicting the risk of type 2 diabetic peripheral neuropathy in Chinese population.
Between the years of 2006 and 2010, a total of 295 definitely diagnosed type 2 diabetes mellitus (T2DM) patients were included into our study cohort and followed for 3 years. At baseline and annual re-examinations, the patients underwent physical examinations, laboratory tests and evaluation of Michigan diabetic neuropathy score (MDNS). Age, gender, disease course, waist-hip circumference ratio (WHR), body mass index (BMI), triglycerine (TG), total cholesterol (Tch), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glycosylated haemoglobin (HbA1c), uric acid elimination rate (UAER) and uric acid (UA) were recorded and GRP78 polymorphisms were tested by direct sequencing. The prognostic significance of GRP78 polymorphisms were analysed using monovariate and multivariate logistic regression.
Three years after baseline, 32.9% (97/295) of the T2DM patients had suffered the development of diabetic peripheral neuropathy and GRP78 rs391957 promoter polymorphism is a significant risk factor for the onset of type 2 diabetic peripheral neuropathy. In monovariate regression model, the OR values of GRP78 rs391957 promoter polymorphism were 2.233 (C/T) and 2.734 (T/T). As for the model calibrated with demographic and laboratory indexes, the OR values were, respectively, 2.124 (C/T) and 2.423 (T/T).
Our study suggested that the GRP78 rs391957 promoter polymorphism is a potential risk factor for type 2 diabetic peripheral neuropathy.
本研究旨在探讨功能性葡萄糖调节蛋白78（GRP78）基因多态性在中国人群中预测2型糖尿病周围神经病变风险的意义。
2006年至2010年间，共295例确诊的2型糖尿病（T2DM）患者纳入研究队列，并随访3年。在基线和每年复查时，患者接受体格检查、实验室检查及密歇根糖尿病神经病变评分（MDNS）评估。记录年龄、性别、病程、腰臀围比（WHR）、体重指数（BMI）、甘油三酯（TG）、总胆固醇（Tch）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、糖化血红蛋白（HbA1c）、尿酸清除率（UAER）和尿酸（UA），并通过直接测序检测GRP78基因多态性。采用单因素和多因素逻辑回归分析GRP78基因多态性的预后意义。
基线3年后，32.9%（97/295）的T2DM患者发生了糖尿病周围神经病变，GRP78 rs391957启动子多态性是2型糖尿病周围神经病变发病的显著危险因素。在单因素回归模型中，GRP78 rs391957启动子多态性的OR值分别为2.233（C/T）和2.734（T/T）。对于经人口统计学和实验室指标校准的模型，OR值分别为2.124（C/T）和2.423（T/T）。
我们的研究表明，GRP78 rs391957启动子多态性是2型糖尿病周围神经病变的潜在危险因素。
