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两例经培养证实的结核分枝杆菌感染病例,表现为宽QRS波心动过速和非干酪样肉芽肿。

Two cases of culture proven Mycobacterium tuberculosis presenting with a broad-complex tachycardia and non-caseating granulomas.

作者信息

Farah Z, Beasley V E, Berry M, Coker R K, Kon O M

机构信息

Hammersmith Hospital, Imperial College Healthcare Trust, London, UK.

出版信息

Respir Med Case Rep. 2014 Apr 16;12:41-3. doi: 10.1016/j.rmcr.2013.10.003. eCollection 2014.

Abstract

Tuberculosis is a leading cause of death worldwide. It affects pulmonary and extra-pulmonary sites with a multitude of differing presentations. In this report, we describe two cases in which TB causes myopericarditis and presents with a broad-complex tachycardia that did not respond typically to standard anti-arrhythmic therapy; a very rare presentation with limited description in the literature. Both patients required extensive investigation culminating in identifying lymph nodes amenable to biopsy under endobronchial ultrasound guidance. It was not until both patients received anti-tuberculous chemotherapy alongside anti-arrhythmic management that any improvement to their condition was witnessed. Therefore, we recommend that the clinician should have a high index of suspicion for TB in any patient presenting with a broad-complex tachycardia that is not responding to standard first line management, especially if the patient is from a high risk background. We recommend an active diagnostic pursuit, and lymph node biopsy under endobronchial ultrasound guidance.

摘要

结核病是全球主要死因之一。它可累及肺部及肺外部位,表现形式多种多样。在本报告中,我们描述了两例结核病导致心肌心包炎并表现为宽QRS波心动过速的病例,这种心动过速对标准抗心律失常治疗通常无反应;这是一种非常罕见的表现,文献中描述有限。两名患者均需要进行广泛检查,最终在内镜超声引导下确定了适合活检的淋巴结。直到两名患者在抗心律失常治疗的同时接受抗结核化疗后,病情才有所改善。因此,我们建议临床医生对于任何出现对标准一线治疗无反应的宽QRS波心动过速的患者,尤其是来自高风险背景的患者,应高度怀疑结核病。我们建议积极进行诊断,并在内镜超声引导下进行淋巴结活检。

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