一种新型谷氨酸衍生物戊二酮的药代动力学特性
Pharmacokinetic Properties of a New Glutamic Acid Derivative Glutaron.
作者信息
Smirnova L A, Ryabukha A F, Kuznetsov K A, Suchkov E A, Perfilova V N, Tyurenkov I N
机构信息
Laboratory of Pharmacological Kinetics, Department of Pharmacology and Biopharmaceutics of the Faculty of Continuing Medical Education, Volgograd State Medical University, Volgograd, Russia.
出版信息
Bull Exp Biol Med. 2015 Jun;159(2):229-31. doi: 10.1007/s10517-015-2929-2. Epub 2015 Jun 20.
Inhomogenous distribution of glutaron in organs and tissues was found after intravenous and peroral administration: the agent demonstrated high affinity to organs with high degree of vascularization (lungs and heart) and elimination (kidney). Glutaron easily penetrates through the blood-brain barrier, which is consistent with its concentration in the adipose tissue.
静脉注射和口服给药后，发现戊二酮在器官和组织中的分布不均匀：该药物对血管化程度高（肺和心脏）以及排泄器官（肾脏）表现出高亲和力。戊二酮易于穿透血脑屏障，这与其在脂肪组织中的浓度一致。
Zotero 插件