Wnt 信号通路下调，肿瘤会被抑制吗？

Wnt Down, Tumors Wind Up?

机构信息

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121. 1066 CX Amsterdam, The Netherlands.

Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121. 1066 CX Amsterdam, The Netherlands; Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, Building 5, Moscow 143026, Russia.

出版信息

Cell. 2015 Jun 18;161(7):1494-6. doi: 10.1016/j.cell.2015.06.008.

DOI:10.1016/j.cell.2015.06.008

PMID:26091030

Abstract

In mouse intestinal tumors induced by the inhibition of APC, the restoration of APC function causes complete tumor regression with normal differentiation and return of stem cell function irrespective of whether tumors also carried mutations in Kras and p53. These findings by Dow et al. validate the Wnt pathway as an exquisite target for intervention.

摘要

在 APC 抑制诱导的小鼠肠道肿瘤中，APC 功能的恢复导致完全的肿瘤消退，伴有正常分化和干细胞功能的恢复，而不论肿瘤是否还携带 Kras 和 p53 的突变。Dow 等人的这些发现验证了 Wnt 通路作为一个干预的精确靶点。