伐尼克兰对健康吸烟者和非吸烟者的Tp-e间期、Tp-e/QT比值及Tp-e/QTc比值的影响。

The effect of varenicline on Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in healthy smokers and nonsmokers.

作者信息

Ari Hasan, Ari Selma, Coşar Selvi, Celiloğlu Nuran, Aktaş İbrahim, Camci Sencer, Doğanay Kübra, Tütüncü Ahmet, Melek Mehmet

机构信息

Bursa Postgraduate Hospital, Depar tment of Cardiology, Bursa, Turkey.

出版信息

Cardiol J. 2015;22(5):551-6. doi: 10.5603/CJ.a2015.0038. Epub 2015 Jun 23.

DOI:10.5603/CJ.a2015.0038

PMID:26100824

Abstract

BACKGROUND

Varenicline could affect the T wave and QT interval. The interval from the peak to the end of the electrocardiographic (ECG) T wave (Tp-e) may correspond to the transmural dispersion of repolarization, and increased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. In this study, we assessed the effects of varenicline on Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio.

METHODS

Thirty healthy volunteers (15 healthy non-smokers [NS] and 15 healthy smokers [S]) were included in the randomized, double-blind, placebo-controlled, crossover study. Varenicline (2 mg single dose) or placebo was administered in two different testing sessions (5 days after the first period, performed the second period). Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio were assessed in the supine position and during handgrip exercise before and after the participants were given placebo or varenicline. Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio were calculated from continuous ECG recordings and averages were used in the final analysis.

RESULT

There were no statistically significant differences among any of the Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio before and after placebo administration in both groups (S and NS). In the S group, Tp-e and QTc interval, and Tp-e/QT and Tp-e/QTc ratio were significantly increased after varenicline administration (Tp-e: 64.28 ± 8.78 vs. 70.42 ± ± 13.12; p = 0.02, QTc: 409.57 ± 28.17 vs. 425.28 ± 32.79; p = 0.02, Tp-e/QT: 0.18 ± 0.02 vs. 0.19 ± 0.03; p = 0.04, Tp-e/QTc: 0.17 ± 0.02 vs. 0.19 ± 0.02; p = 001) but these parameters were not changed in the NS group.

CONCLUSIONS

Tp-e and QTc interval, and Tpe/QT and Tpe/QTc ratio were increased after varenicline administration in smokers.

摘要

背景

伐尼克兰可能影响T波和QT间期。心电图（ECG）T波从峰值到结束的间期（Tp-e）可能对应复极的跨壁离散度，Tp-e间期和Tp-e/QT比值增加与恶性室性心律失常相关。在本研究中，我们评估了伐尼克兰对Tp-e间期、Tp-e/QT比值和Tp-e/QTc比值的影响。

方法

30名健康志愿者（15名健康非吸烟者[NS]和15名健康吸烟者[S]）被纳入随机、双盲、安慰剂对照、交叉研究。在两个不同的测试阶段给予伐尼克兰（单次剂量2 mg）或安慰剂（在第一阶段后5天进行第二阶段）。在给予安慰剂或伐尼克兰之前和之后，评估受试者仰卧位和握力运动时的Tp-e间期、Tp-e/QT比值和Tp-e/QTc比值。Tp-e间期、Tp-e/QT比值和Tp-e/QTc比值根据连续的心电图记录计算得出，最终分析采用平均值。

结果

两组（S组和NS组）在给予安慰剂前后，Tp-e间期、Tp-e/QT比值和Tp-e/QTc比值中的任何一项均无统计学显著差异。在S组中，给予伐尼克兰后Tp-e和QTc间期以及Tp-e/QT和Tp-e/QTc比值显著增加（Tp-e：64.28±8.78对70.42±13.12；p = 0.02，QTc：409.57±28.17对425.28±32.79；p = 0.02，Tp-e/QT：0.18±0.02对0.19±0.03；p = 0.04，Tp-e/QTc：0.17±0.02对0.19±0.02；p = 0.01），但这些参数在NS组中未改变。