结肠癌中δ样蛋白4（果蝇）和血管内皮生长因子A的表达及其与肿瘤血管生成的关系

Expression of delta-like 4 (Drosophila) and vascular endothelial growth factor A in colon cancer and association with tumour angiogenesis.

作者信息

Zheng Yongbin, Hao Zhinan, Ding Yu, Wang Qiushuang, Li Shengbo, Xiao Gaochun, Luo Haiping, Shi Qiang, Tong Shilun

机构信息

Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, China

Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, China.

出版信息

J Int Med Res. 2015 Aug;43(4):535-43. doi: 10.1177/0300060513507388. Epub 2015 Jun 25.

DOI:10.1177/0300060513507388

PMID:26111775

Abstract

OBJECTIVE

Angiogenesis depends on interaction between a variety of promoting and inhibiting factors, and is known to involve vascular endothelial growth factor (VEGF) A and the Notch signaling pathway. The present study investigated the expression of Notch ligand delta-like (DLL) 4 (Drosophila), and VEGFA in colon cancer and colorectal adenoma tissue, and the association with tumour angiogenesis.

METHODS

Protein level DLL4, VEGFA and CD34 molecule (CD34) expression was detected immunohistochemically in tissue sections from patients with colon cancer and colorectal adenoma.

RESULTS

Out of 80 cases (35 with colon cancer, 45 with colorectal adenoma) DLL4 and VEGFA expression was closely related to tumour diameter, clinical stage, histological grade and lymph node metastasis. DLL4 expression was significantly higher in colon cancer tissue than colorectal adenoma tissue.

CONCLUSION

High levels of DLL4 expression were closely related to metastasis and prognosis in patients with colon cancer. The results of the present study support the conclusion that prognosis of colon cancer is significantly correlated with angiogenesis.

摘要